肝细胞生长因子及其受体c-Met在结直肠癌中的表达及其意义  

Expression and Significance of Hepatocyte Growth Factor and Its Receptor C-Met in Colorectal Cancer

作　　者：徐永良[1] 刘贵波[1] 马英[2] 李明秋[1] 潘艳明[1] 赵微[1] XU Yongliang;LIU Guibo;MA Ying;LI MingQIU;PAN Yanming;ZHAO Wei(Anatomy Teaching and Research Department,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011;Library,Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011)

机构地区：[1]牡丹江医学院解剖教研室,黑龙江牡丹江157011 [2]牡丹江医学院图书馆,黑龙江牡丹江157011

出　　处：《智慧健康》2024年第27期61-64,共4页Smart Healthcare

基　　金：黑龙江省省属高等学校基本科研业务费科研项目《肝细胞生长因子介导的EMT在结直肠癌血管生成中的作用机制》(项目编号:2020-KYYWF-0797)。

摘　　要：目的探讨结直肠癌中肝细胞生长因子及其受体c-Met表达及其意义。方法选取2020年2月—2022年2月在牡丹江医学院附属第二医院接受治疗的结直肠癌患者126例作为病例组,并选取同期40例正常结肠组织及良性腺瘤作为对照组。统计分析两组结直肠组织中微淋巴管密度(microlymphatic density,LMVD)表达、HGF及其受体c-Met阳性表达情况,统计分析病例组结直肠癌组织中不同临床指标患者的LMVD、肝细胞生长因子(hepatocyte growth factor,HGF)及其受体细胞间质上皮转换因子(cellular-mesenchymal epithelial transition factor,c-Met)表达。结果病例组患者结直肠组织中LMVD表达高于参照组(P<0.05)。病例组病理分期Ⅰ+Ⅱ期、有淋巴结转移患者的结直肠癌组织中LMVD分别低于病理分期Ⅲ+Ⅳ期、无淋巴结转移患者(P<0.05),HGF阳性、c-Met阳性患者的结直肠癌组织中LMVD分别高于HGF阴性、c-Met阴性患者(P<0.05)。病例组患者结直肠组织中HGF及其受体c-Met阳性表达率均高于参照组(P<0.05)。病例组病理分期Ⅰ+Ⅱ期结直肠癌组织中HGF及其受体c-Met阳性表达率均高于Ⅲ+Ⅳ期患者(P<0.05),有淋巴结转移患者的结直肠癌组织中HGF及其受体c-Met阳性表达率均低于无淋巴结转移患者(P<0.05)。结论结直肠癌中肝细胞生长因子及其受体c-Met阳性表达提升,病理分期越高阳性率越高、有淋巴结转移阳性率升高,可能成为治疗新靶点。Objective To investigate the expression and significance of hepatocyte growth factor and its receptor c-Met in colorectal cancer.Methods The paper reviewed and chose 126 patients with colorectal cancer in Mudanjiang Medical University the Second Affiliated Hospital from February 2020 to February 2022 as the case group,and 40 cases with surrounding normal colon tissue and benign adenomas as the reference group.The expression of microlymphatic density(LMVD),HGF,and its receptor c-Met positive in colorectal tissues of two groups,and the expression of LMVD,hepatocyte growth factor(HGF)and its receptor cellular-mesenchymal epithelial transition factor(c-Met)of patients with different clinical indicators of colorectal cancer tissues in the case group was analyzed statistically.Results The expression of LMVD in colorectal tissue of patients in the case group was higher than the control group(P<0.05).The LMVD in colorectal cancer tissues of patients with pathological stage I+Ⅱand lymph node metastasis was lower than those of pathological stageⅢ+Ⅳand without lymph node metastasis(P<0.05).The LMVD in colorectal cancer tissues of HGF positive and c-Met positive patients was higher than HGF negative and c-Met negative patients(P<0.05).The positive expression rates of HGF and its receptor c-Met in colorectal tissues of the case group were higher than the reference group(P<0.05).The positive expression rates of HGF and its receptor c-Met in the colorectal cancer tissues with pathological stage I+Ⅱof the case group were higher than those of stageⅢ+Ⅳ,(P<0.05).The positive expression rates of HGF and its receptor c-Met in colorectal cancer tissues of patients with lymph node metastasis were lower than those without lymph node metastasis(P<0.05).Conclusion The increase of positive expression of hepatocyte growth factor and its receptor c-Met in colorectal cancer,and increase of positive rate of lymph node metastasis may become a new curative target,and the higher the pathological stage,the higher the positive rate.

关 键 词：结直肠癌 肝细胞生长因子 受体C-MET 表达 意义 

分 类 号：R735.34[医药卫生—肿瘤]