磺酸化β-环糊精催化合成1,4-二氢吡啶  

Synthesis of 1,4-dihydropyridines catalyzed byβ-cyclodextrin-SO_(3)H

作　　者：李文欢 王英磊[1,2] 田野 曹春 LI Wen-huan;WANG Ying-lei;TIAN Ye;CAO Chun(School of Biological and Chemical Engineering,Nanyang Institute of Technology,Nanyang 473004,China;Henan Key Laboratory of Industrial Microbial Resources and Fermentation Technology,Nanyang Institute of Technology,Nanyang 473004,China)

机构地区：[1]南阳理工学院生物与化学工程学院,河南南阳473004 [2]南阳理工学院,河南省工业微生物资源与发酵技术重点实验室,河南南阳473004

出　　处：《化学研究与应用》2024年第12期2944-2950,共7页Chemical Research and Application

基　　金：南阳市基础与前沿技术研究计划项目(JCQY007)资助;南阳理工学院交叉科学研究项目(520063)资助。

摘　　要：β-环糊精是一种由生物发酵技术生产的环状低聚糖,由于其分子中含有多种类型的羟基活性基团,可通过选择性的化学反应进行修饰,从而制得环境友好的生物质基催化剂。利用β-环糊精与氯磺酸的反应,制备了磺酸化β-环糊精(β-CD-SO_(3)H)固体酸催化剂,在无溶剂条件下催化醛、乙酰乙酸乙酯(或乙酰乙酸甲酯)和乙酸铵反应,以85~97%的产率合成了一系列1,4-二氢吡啶衍生物。β-Cyclodextrin is a cyclic oligosaccharide produced by biological fermentation technology.β-Cyclodextrin could be modi-fied through selective chemical reactions to produce environmental-friendly biomass based catalysts,due to various types of hydroxyl active groups.The solid acid ofβ-cyclodextrin-SO_(3)H(β-CD-SO,H)was prepared by the reaction ofβ-cyclodextrin with chlorosulfon-ic acid.β-CD-SO,H was applied as the catalyst for the synthesis of a series of 1,4-dihydropyridine derivatives through the reaction of aldehydes,ethyl acetoacetate(or methyl acetoacetate),and ammonium acetate under solvent-free conditions,in yields of 85%to 97%.

关 键 词：磺酸化β-环糊精 1 4-二氢吡啶 绿色合成 循环利用 

分 类 号：O626.3[理学—有机化学]