Mechanobiology research in China  

作　　者：Zong-Lai Jiang 

机构地区：[1]Institute of Mechanobiology&Medical Engineering,School of Life Sciences&Biotechnology,Shanghai Jiao Tong University,P.O.Box 888,800 Dongchuan Road,Minhang,Shanghai,200240,China

出　　处：《Mechanobiology in Medicine》2023年第1期17-27,共11页力学生物学与医学（英文）

基　　金：supported by the National Natural Science Foundation of China,Nos.11972232,31670958,11542006,11232010,10732070,3047032,and 10132020.

摘　　要：Mechanobiology is an interdisciplinary discipline combining biology,engineering,chemistry,physics,and medicine.Mechanobiology research comprehensively discusses,the role of mechanical factors in various life processes and the occurrence and development of associated and diseases at the whole organism,organ,cell,protein and gene levels.The cellular and molecular mechanisms of mechanical signal transduction and response are elucidated,in addition to the discovery of novel biomarkers and potential drug targets,which are mechanosensitive molecules.This paper reviews the development of mechanobiology research in China since the new century,while focusing on the research achievements of Chinese scientists in the field of mechanobiology over the last three years,including cardiovascular,bone and joint,tumor,cellular,and molecular mechanobiology.Meanwhile,it has been suggested that in the future,mechanobiology research should include are indicated detailed studies on the mechanobiological mechanism of diseases at the cellular and molecular levels firstly,so that the newly discovered biomarkers or potential targets can gradually achieve clinical transformation.Second,future research should strengthen the qualitative and quantitative combination of biological experiments and mechanical and mathematical modeling analyses,especially at cellular,subcellular and molecular scales.Mechanobiological studies are of great theoretical and practical significance for our understanding of the mechanical mechanisms and natural laws of growth and senility of the human body,expounding pathological mechanisms of diseases,and researching and developing new medicines and technologies to promote biomedical and clinical research for human health.

关 键 词：MECHANOTRANSDUCTION Cardiovascular disease OSTEOARTHROPATHY Tumor mechano-microenvironment Mechanosensitive molecule 

分 类 号：R318[医药卫生—生物医学工程]