食管癌患者外周血NLR、CAR与术后早期吻合口瘘的关系研究  

Relationship between peripheral blood NLR and CAR and early postoperative anastomotic leakage in esophageal cancer patients

作　　者：刘琳 苏春勇[1] 范焕芳[2] LIU Lin;SU Chunyong;FAN Huanfang(First Department of Chest Surgery,Handan Central Hospital,Handan,Hebei 056001,China;Department of Oncology,Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang,Hebei 050013,China)

机构地区：[1]邯郸市中心医院胸外一科,河北邯郸056001 [2]河北省中医院肿瘤内科,河北石家庄050013

出　　处：《国际检验医学杂志》2024年第24期2995-2998,共4页International Journal of Laboratory Medicine

基　　金：河北省中医药管理局中医药类科研计划(2020001)。

摘　　要：目的 探讨食管癌患者外周血中性粒细胞/淋巴细胞比值(NLR)、C反应蛋白/白蛋白比值(CAR)与术后早期吻合口瘘(AL)的关系。方法 回顾性纳入2016年12月至2024年1月于邯郸市中心医院就诊并接受食管切除术的116例食管癌患者作为研究对象,并依据患者术后7 d内是否发生AL将患者分为AL组(21例)与非AL组(95例)。收集患者一般资料,检测所有患者外周血中性粒细胞、淋巴细胞、C反应蛋白、白蛋白水平,计算NLR、CAR。多因素Logistic回归分析影响食管癌患者术后早期AL的因素。受试者工作特征(ROC)曲线分析NLR、CAR及联合对食管癌患者术后早期AL的预测价值。结果 AL组外周血NLR、CAR高于非AL组,手术时间短于非AL组(P<0.05)。多因素Logistic回归分析结果显示,NLR、CAR是食管癌患者术后早期AL的危险因素(P<0.05)。ROC曲线结果显示,NLR、CAR及联合预测患者术后早期AL的曲线下面积(AUC)为0.875、0.871、0.958,联合预测的AUC大于单独预测(Z=2.274、2.927,P<0.05)。结论 食管癌患者外周血NLR、CAR与术后早期AL密切相关。Objective To explore the relationship between peripheral blood neutrophil/lymphocyte ratio(NLR),C-reactive protein/albumin ratio(CAR)and early postoperative anastomotic leakage in patients with esophageal cancer.Methods A total of 116 esophageal cancer patients who were treated in Handan Central Hospital and underwent esophagectomy from December 2016 to January 2024 were retrospectively included as research objects,and the patients were divided into AL group(21 cases)and non-AL group(95 cases)based on whether AL occurred within 7 days after surgery.General information of patients was collected,peripheral blood neutrophil,lymphocyte,C-reactive protein,and albumin levels of all patients were measured,and NLR and CAR were calculated.Multivariate Logistic regression was used to analyze the factors affecting early postoperative AL in patients with esophageal cancer.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of NLR,CAR and their combination for early postoperative AL in patients with esophageal cancer.Results The peripheral blood NLR and CAR in the AL group were higher than those in the non-AL group,and the operation time was shorter than that in the non-AL group(P<0.05).Multivariate Logistic regression analysis results showed that NLR and CAR were risk factors for early postoperative AL in esophageal cancer patients(P<0.05).The ROC curve results showed that the area under the curve(AUC)of NLR,CAR and combined prediction of early postoperative AL in patients were 0.875,0.871,and 0.958,and the AUC of combined prediction was greater than that of individual prediction(Z=2.274,2.927,P<0.05).Conclusion Peripheral blood NLR and CAR in patients with esophageal cancer are closely related to early postoperative AL.

关 键 词：食管癌 食管切除术 中性粒细胞/淋巴细胞比值 C反应蛋白/白蛋白比值 早期吻合口瘘 

分 类 号：R735.1[医药卫生—肿瘤]