血管平滑肌细胞表型转换与细胞焦亡在腹主动脉瘤中的作用及研究进展  

Research progress in the role of vascular smooth muscle cell phenotype switching and cell pyroptosis in abdominal aortic aneurysm

作　　者：刘欣 唐红悦[2] 郭畅 马冬 张明明 LIU Xin;TANG Hongyue;GUO Chang;MA Dong;ZHANG Mingming(Graduate School of Hebei Medical University,Shijiazhuang 050017,China;Blood Transfusion Department,Hebei General Hospital,Shijiazhuang 050051;Graduate School,North China University of Science and Technology,Tangshan 063210;Department of Biochemistry,School of Basic Medicine,Hebei Medical University,Shijiazhuang 050017;Clinical Medicine Research Cener,Hebei General Hospital,Shijiazhuang 050051;Hebei Key Laboratory of Metabolic Diseases,Shijiazhuang 050051)

机构地区：[1]河北医科大学研究生学院,石家庄050017 [2]河北省人民医院输血科,石家庄050051 [3]华北理工大学研究生院,河北唐山063210 [4]河北医科大学基础医学院生化研究室,石家庄050017 [5]河北省人民医院临床医学研究中心,石家庄050051 [6]河北省代谢病重点实验室,石家庄050051

出　　处：《中国比较医学杂志》2024年第11期100-106,共7页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82270508);河北省自然科学基金面上项目(H2024307005);神经与血管生物学教育部重点实验室主任基金青年基金项目(NV20210006);河北省人社厅重点研发计划项目(A202105015)。

摘　　要：腹主动脉瘤(abdominal aortic aneurysm,AAA)作为一种隐匿型致死性疾病,其背后的发展机制尚不清楚。研究已经发现血管平滑肌细胞(vascular smooth muscle cell,VSMCs)表型转换和细胞焦亡(cell pyroptosis)是与AAA产生发展密切相关的两种生物学过程,可能会成为揭示AAA发生机制的重要学说,为AAA的诊断和治疗提供新的方向。本文将通过介绍VSMCs表型转换和细胞焦亡与AAA之间的调控关系展开论述。Abdominal aortic aneurysm(AAA)is a hidden and fatal disease,but its underlying developmental mechanism remains unclear.Phenotypic switching of vascular smooth muscle cells and pyroptosis have been identified as biological processes closely related to the appearance and progression of AAA,with potentially important roles in the mechanism of AAA and in providing new directions for its diagnosis and treatment.In this review,we discuss phenotypic switching of vascular smooth muscle cells and the regulatory relationship between cell pyroptosis and AAA.

关 键 词：细胞焦亡 表型转换 动脉粥样硬化性疾病 腹主动脉瘤 

分 类 号：R-33[医药卫生]