PCOS中胰岛素抵抗、高雄激素血症与线粒体氧化应激的关系探讨  

Relationship between insulin resistance,hyperandrogenism,and mitochondrial oxidative stress in polycystic ovarian syndrome

作　　者：赵琦 陈萍[2] 杨丽萍 孙建华 马子博[1] ZHAO Qi;CHEN Ping;YANG Liping;SUN Jianhua;MA Zibo(the First Clinical Medical College,Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China.2.Department of Obstetrics and Gynecology,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000)

机构地区：[1]河南中医药大学第一临床医学院,郑州450046 [2]河南中医药大学第一附属医院妇产科,郑州450000

出　　处：《中国比较医学杂志》2024年第11期126-131,共6页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(81973596);河南中医药大学博士科研启动基金项目(RSBSJJ2019-29);河南中医药大学重点学科建设项目(15102044-2020);河南省中医药传承与创新人才工程(仲景工程)中医药青苗人才培养项目(豫卫中医函[2021]16号)。

摘　　要：多囊卵巢综合征(polycystic ovarian syndrome,PCOS)是一种常见于妇产科的生殖内分泌代谢疾病。胰岛素抵抗(insulin resistance,IR)、高雄激素血症(hyperandrogenemia,HA)是PCOS的两个重要特征,在其发生发展过程中起到重要作用。有研究发现,PCOS患者与线粒体氧化应激存在一定关系,这种氧化应激又受到多种因素的影响,尤其是IR和HA。该文综述了IR和HA与线粒体氧化应激之间的关系,以及对PCOS患者线粒体氧化应激的影响。Polycystic ovarian syndrome(PCOS)is a prevalent reproductive endocrine metabolic disorder within obstetrics and gynecology.Two pivotal features of PCOS,insulin resistance(IR)and hyperandrogenemia(HA),are both instrumental in its pathogenesis.There exists a discernible correlation between PCOS and mitochondrial oxidative stress,a relationship heavily influenced by various factors,most notably IR and HA.This article endeavors to elucidate the interplay between IR,HA,and mitochondrial oxidative stress while also exploring the impacts of insulin resistance and hyperandrogenemia on mitochondrial oxidative stress among PCOS patients.

关 键 词：多囊卵巢综合征 胰岛素抵抗 高雄激素血症 线粒体 氧化应激 

分 类 号：R-33[医药卫生]