缺氧细胞模型的研究进展  

Research progress on hypoxic cell models

作　　者：李靖 徐东阳 李昌卿 苏梦瑶 王志娟 赵明俊 赵家龙 杨君仪 杨巧蝶 康龙丽 LI Jing;XU Dongyang;LI Changqing;SU Mengyao;WANG Zhijuan;ZHAO Mingjun;ZHAO Jialong;YANG Junyi;YANG Qiaodie;KANG Longli(School of Basic Medicine,Ministry of Medicine,Xizang Minzu University,Xianyang 712082,China;Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region,Xizang Minzu University,Xianyang 712082;Key Laboratory of High Altitude Environment and Genes Related to Disease of Tibet Autonomous Region,Xizang Minzu University,Xianyang 712082)

机构地区：[1]西藏民族大学医学部基础医学院,陕西咸阳712082 [2]西藏民族大学高原相关疾病分子遗传机制与干预研究重点实验室,陕西咸阳712082 [3]西藏民族大学高原环境与疾病相关机理研究高校重点实验室,陕西咸阳712082

出　　处：《中国比较医学杂志》2024年第11期132-144,共13页Chinese Journal of Comparative Medicine

基　　金：西藏民族大学“青年学人培育计划”资助项目(21MDX03);西藏高原相关疾病分子机制与干预研究重点实验室开放项目(KF2022005);国家自然科学基金(U20A20395,82460333);西藏自治区基基地与人才基金(XZ202401JD0031);藏秦喜马拉雅·人才发展支持计划“高峰学者”(202001)。

摘　　要：在临床上,许多疾病的发生与发展过程中常伴随着细胞缺氧的现象。缺氧不仅是疾病进展的一个重要标志,而且在推动疾病进程中也扮演着关键角色。因此,改善组织缺氧可能为治疗相关疾病提供新的策略。为了从细胞和分子层面深入研究这类疾病,构建细胞缺氧模型显得尤为重要。目前,常用的缺氧细胞模型主要分为化学性缺氧模型、物理性缺氧模型和糖氧剥夺(oxygen glucose deprivation,OGD)模型。本文将对不同类型的缺氧细胞模型进行综述,探讨在疾病研究中的应用与局限性。Hypoxia is associated with the occurrence and development of many diseases in clinical settings.Cell hypoxia not only serves as a vital marker for disease advancement,but also plays a pivotal role in exacerbating the disease process,and improving tissue hypoxia may thus provide new strategies for the treatment of related diseases.Further investigation of these diseases at the cellular and molecular levels requires the establishment of a cellular hypoxia model.Current extensively employed hypoxic cell models can be categorized primarily into three types:chemical hypoxia,physical hypoxia,and glucose deprivation hypoxia models.This article reviews the various types of hypoxic cell models and scrutinizes their applications and limitations in disease research.

关 键 词：缺氧细胞 物理缺氧 化学缺氧 复氧 

分 类 号：R-33[医药卫生]