PPARγ基因在骨关节炎中作用机制及其关键信号通路作用的研究进展  

Research progress in the mechanism and role of key signaling pathways of the peroxisome proliferator-activated receptorγgene in osteoarthritis

作　　者：张建[1] 王冬 齐天天 吴凉彬 杨琪 于斐 ZHANG Jian;WANG Dong;QI Tiantian;WU Liangbin;YANG Qi;YU Fei(Peking University Shenzhen Hospital,Shenzhen 518036,China;Binzhou City Bincheng District Municipal Hospital,Binzhou 256600;National&Local Joint Engineering Research Center of Orthopedic Biomaterials,Shenzhen 518036;Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research,Shenzhen 518036;Shenzhen Second People’s Hospital,Shenzhen 518035)

机构地区：[1]北京大学深圳医院,广东深圳518036 [2]滨州市滨城区市立医院,山东滨州256600 [3]骨科生物材料国家地方联合工程研究中心,广东深圳518036 [4]深圳市骨科疾病与生物材料研究重点实验室,广东深圳518036 [5]深圳市第二人民医院,广东深圳518035

出　　处：《中国比较医学杂志》2024年第11期145-152,共8页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82102076);广东省基础与应用基础研究基金项目(2022A1515220111,2022A1515220055,2021A1515110311)。

摘　　要：骨关节炎(osteoarthritis,OA)是中老年人群中发病率较高的一种慢性退行性疾病,可导致患者关节疼痛、畸形和功能障碍,给患者及家庭造成痛苦。过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)是近年来发现的一种配体依赖的转录调节因子,可调控脂肪和糖类代谢、炎症及免疫进程。研究显示,PPARγ基因对OA软骨退变、滑膜炎症、脂肪病变起重要作用,并可通过腺苷酸活化蛋白激酶(AMPK)、Wnt、沉默信息调节因子1(SIRT1)等信号通路影响OA进展。本文就PPARγ基因通过关节相关组织及关键信号通路调控OA病变的作用及机制作一综述。Osteoarthritis(OA)is a chronic degenerative disease with a high incidence rate among middle-aged and elderly people.It can cause joint pain,deformity,and functional impairment,leading to a heavy burden on patients and their families.Peroxisome proliferator-activated receptorγ(PPARγ)is a recently discovered ligand-dependent transcriptional regulatory factor that can regulate fat and carbohydrate metabolism,inflammation,and immune processes.Research has shown that the PPARγgene plays an important role in OA cartilage degeneration,synovitis inflammation,and adipose lesions,and can affect OA progression through signaling pathways such as the AMP-activated protein kinase,Wnt,and sirtuin 1 pathways.This review focuses on the role and mechanism of the PPARγgene in OA,in relation to jointrelated tissues and key signaling pathways.

关 键 词：PPARΓ基因 骨关节炎 关节组织 信号通路 作用机制 

分 类 号：R-33[医药卫生]