表观遗传学在运动改善帕金森障碍中的作用机制研究进展  

Research progress in the roles of epigenetic mechanisms in improving Parkinson’s disease through exercise

作　　者：刘波 陈祥和[2] 陆鹏程 杨康 LIU Bo;CHEN Xianghe;LU Pengcheng;YANG Kang(Jiangsu College of Tourism Office of Physical Education,Yangzhou 225127,China;School of Physical Education,Yangzhou University,Yangzhou 225127;Yancheng Ocean Vocational School,Yancheng,224145;Department of Rehabilitation Medicine,Subei People’s Hospital,Yangzhou 225127)

机构地区：[1]江苏旅游职业学院体育部,江苏扬州225127 [2]扬州大学体育学院,江苏扬州225127 [3]盐城海洋职业学校,江苏盐城224145 [4]江苏省苏北人民医院康复医学科,江苏扬州225127

出　　处：《中国比较医学杂志》2024年第11期153-162,共10页Chinese Journal of Comparative Medicine

基　　金：国家社会科学基金教育学青年课题(CLA200279);中国博士后科学基金特别资助(2021T140580);中国博士后科学基金面上资助(2019M661957);江苏省哲学社会科学基金(20TYC001)。

摘　　要：帕金森病(Parkinson's disease,PD)是一种高度复杂的神经退行性疾病,其发病机制受DNA甲基化、组蛋白修饰、非编码RNA的影响。在对帕金森患者脑组织及血液的研究中表明,DNA甲基化/组蛋白修饰水平改变、ncRNA及其靶基因的变异可能引发大脑神经退行性变化,并作为帕金森病的潜在非侵入性生物标志物。运动可通过逆转表观遗传改善衰老、PD引发的神经退行性病变。本文综述表观遗传在PD中的发病机制,探讨运动在其中扮演的角色,为运动通过调节表观遗传机制来改善PD提供理论参考。Parkinson’s disease(PD)is a highly complex neurodegenerative disease,and its pathogenesis is influenced by DNA methylation,histone modification,and non-coding RNA.Research on Parkinson’s brain tissue and blood has shown that changes in DNA methylation/histone modification levels and variations in ncRNA and its target genes may trigger neurodegeneration changes in the brain and serve as potential non-invasive biomarkers for PD.Exercise can ameliorate the neurodegenerative diseases caused by aging and PD by reversing epigenetic changes.This article reviews the role of epigenetics in the pathogenesis of PD,explores the benefits of exercise,and provides a theoretical reference for research into improving PD by regulating epigenetics through exercise.

关 键 词：表观遗传学 帕金森病 运动 机制 

分 类 号：R-33[医药卫生]