小胶质细胞胞葬在阿尔茨海默病中的作用研究进展  

Research progress on the role of microglia efferocytosis in Alzheimer’s disease

作　　者：马驰远 王新志[1] 刘向哲[1] 韩珍珍 郭明 刘昊飞[1] 李潇[5] MA Chiyuan;WANG Xinzhi;LIU Xiangzhe;HAN Zhenzhen;GUO Ming;LIU Haofei;LI Xiao(Department of Brain Disease Center,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;the First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000;Zhengzhou Jinshui District General Hospital,Zhengzhou 450000;Zhengzhou Weilai Road Street Elder Care Center,Zhengzhou 450000;Henan University of Chinese Medicine,Zhengzhou 450046)

机构地区：[1]河南中医药大学第一附属医院脑病中心,郑州450000 [2]河南中医药大学第一临床医学院,郑州450000 [3]郑州市金水区总医院,郑州450000 [4]郑州市未来路街道养老中心,郑州450000 [5]河南中医药大学,郑州450046

出　　处：《中国比较医学杂志》2024年第11期163-168,共6页Chinese Journal of Comparative Medicine

基　　金：中医药传承与创新“百千万”人才工程(岐黄工程)-国家中医药领军人才支持计划(国中医药人教发[2018]12号);河南省中医药传承与创新人才工程(仲景工程)中医药学科领军人才(豫卫中医函[2021]8号);河南省科技攻关项目(242102311277);国家资助博士后研究人员计划(GZC20240442);河南省自然科学基金(232300420271);河南省中医药科学研究专项(2022JDZX116)。

摘　　要：小胶质细胞胞葬作用是指小胶质细胞吞噬受损和死亡细胞的过程,具有抗炎和促损伤修复的作用。最新研究表明,小胶质细胞胞葬在阿尔茨海默病(Alzheimer's disease,AD)病理过程中发挥重要作用,可能是治疗AD的新靶标。因此本文综述了小胶质细胞胞葬与AD病理机制的关系以及胞葬相关分子作为AD治疗靶标的潜力,以期为AD的治疗提供新思路和新方法。Microglia efferocytosis,the process by which microglia phagocytose damaged and dead cells,has antiinflammatory and pro-damage repair effects.Recent studies have shown that microglia efferocytosis plays a crucial role in the pathogenesis of Alzheimer’s disease(AD)and may be a novel therapeutic target for AD.This paper reviews the relationship between microglia efferocytosis and AD pathogenesis and the potential of using efferocytosis-related molecules as therapeutic targets for AD.The aim of this review is to provide new ideas and approaches for the treatment of AD.

关 键 词：小胶质细胞 胞葬 阿尔茨海默病 认知障碍 神经炎症 

分 类 号：R-33[医药卫生]