通过自由基历程烯烃1,2-双官能团化反应同时构建C―O键和C―X键研究进展  

Research Progress on the Simultaneous Construction of C―O and C―X Bonds via 1,2-Difunctionalization of Olefins through Radical Pathways

作　　者：吴丹清 刘佳俊 李天宇 徐大振[1] 苗志伟[1] Danqing Wu;Jiajun Liu;Tianyu Li;Dazhen Xu;Zhiwei Miao(State Key Laboratory of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China)

机构地区：[1]南开大学化学学院,元素有机化学国家重点实验室,天津300071

出　　处：《大学化学》2024年第11期146-157,共12页University Chemistry

基　　金：国家自然科学基金面上项目(22071113);福建省南平市科技项目(N2020Z008)。

摘　　要：通过自由基途径的烯烃1,2-双官能团化反应是有机合成中从烯烃直接构建C―X(X=C,N,O…)键的重要手段,其优点包括良好的区域选择性、步骤经济性和原子经济性,符合绿色化学的发展要求。含有碳-氧键的有机功能化合物种类很多,发展简单高效构建碳-氧键的合成方法是有机化学家广泛关注的研究领域。本文综述了在构建碳-氧键的同时,构建碳-碳键、碳-氮键、碳-硫键和碳-卤键的反应研究进程,并对该领域的未来发展方向进行了展望。The 1,2-difunctionalization of olefins via radical pathways is a crucial method in organic synthesis for the direct formation of C―X(X = C,N,O,etc.) bonds from olefins.This approach offers several advantages,including high regioselectivity,step economy,and atom economy,making it compatible with the principles of green chemistry.The development of simple and efficient methods for constructing carbon-oxygen bonds is a significant area of interest in organic chemistry due to the prevalence of organic functional compounds containing these bonds.This review summarizes the recent progress in constructing carbon-oxygen bonds concurrently with carbon-carbon,carbonnitrogen,carbon-sulfur,and carbon-halogen bonds.Additionally,the article discusses the future directions for research in this field.

关 键 词：烯烃 1 2-双官能团化 碳-氧键构建 区域选择性 研究进展 自由基历程 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]