具有轴手性化合物的对映选择性合成研究进展  

Research Progress in Enantioselective Synthesis of Axial Chiral Compounds

作　　者：赵熙林 涂星宇 李宗宣 董锐 蒋博 苗志伟[1] Xilin Zhao;Xingyu Tu;Zongxuan Li;Rui Dong;Bo Jiang;Zhiwei Miao(State Key Laboratory of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China.)

机构地区：[1]南开大学化学学院,元素有机化学国家重点实验室,天津300071

出　　处：《大学化学》2024年第11期158-173,共16页University Chemistry

基　　金：国家自然科学基金面上项目(22071113);福建省南平市科技项目(N2020Z008)。

摘　　要：轴手性化合物具有独特的手性结构,在不对称催化、医药、光电材料和天然产物等诸多领域具有重要应用。近年来轴手性化合物对映选择性合成取得了较大的研究进展,在手性轴的类型上除了传统的C―C轴和C―N轴以外,N―N轴、C―S轴、C―O轴和C―B轴手性化合物的不对称合成也取得了新的突破。本文综述了近年来各类轴手性化合物不对称合成的研究进展,并对该领域未来的发展方向进行了展望。Axially chiral compounds possess unique chiral structures and have significant applications across diverse fields such as asymmetric catalysis,pharmaceuticals,optoelectronic materials,and natural products.In recent years,substantial advancements have been achieved in the enantioselective synthesis of these compounds.Beyond the conventional C―C and C―N axial chiral compounds,notable breakthroughs have been realized in the asymmetric synthesis of chiral compounds featuring N―N,C―S,C―O,and C―B axes.This review summarizes the recent progress in the asymmetric synthesis of various axially chiral compounds and discusses future directions in this research area.

关 键 词：轴手性化合物 对映选择性合成 研究进展 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]