微波促进下沙芬酰胺甲磺酸盐的合成  

Microwave-Assisted Synthesis of Safinamide Methanesulfonate

作　　者：于月娜 房芳 Yuena Yu;Fang Fang(Department of Chemistry,Southern University of Science and Technology,Shenzhen 518055,Guangdong Province,China.)

机构地区：[1]南方科技大学化学系,广东深圳518055

出　　处：《大学化学》2024年第11期210-216,共7页University Chemistry

基　　金：南方科技大学高等教育教学改革项目(Y01211842)。

摘　　要：本文基于一款治疗阿兹海默症的药物——沙芬酰胺甲磺酸盐进行教学设计,以4-(3-氟苄氧基)苯甲醛为起始原料,引入微波合成技术,采用还原胺化策略,经过三步反应,迅速、高效得到目标产物,并采用核磁、熔点和旋光分析方法鉴定结构与纯度。实验设置既兼顾有机综合实验技术的训练,又注重知识的交叉融合。This study focuses on the design of a teaching experiment of synthesizing safinamide methanesulfonate,a drug for treating Alzheimer's disease.Starting from 4-(3-fluorobenzyloxy)benzaldehyde,the microwave synthesis technique was employed in a reductive amination strategy to rapidly and efficiently obtain the target product through three consecutive reactions.The product's structure and purity were confirmed through NMR,melting point,and specific rotation analysis.This experiment not only enhances students' organic synthesis skills but also emphasizes the integration of knowledge across disciplines.

关 键 词：沙芬酰胺 微波合成 还原胺化 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]