CA15-3、TPS结合SPECT/CT核素骨显像诊断乳腺癌骨转移的临床价值  

Clinical Values of CA15-3,TPS Combined with SPECT Radionuclide BoneImaging in the Diagnosis of Bone Metastasis of Breast Cancer

作　　者：姜振伟 吴江 JIANG Zhenwei;WU Jiang(Laboratory of Wuhan Puren Hospital,Wuhan 430000,China;Laboratory of YangxinCounty Maternal and Child Health Care Hospital,Yangxin 430081,China)

机构地区：[1]武汉市普仁医院检验科,湖北武汉430000 [2]阳新县妇幼保健院检验科,湖北阳新430081

出　　处：《标记免疫分析与临床》2024年第11期2003-2007,共5页Labeled Immunoassays and Clinical Medicine

摘　　要：目的评价血清糖链抗原153(carbohydrate antigen 15-3,CA15-3)水平、血清组织多肽特异性抗原(tissue polypeptide specific antigen,TPS)水平结合SPECT/CT核素骨显像应用于患骨转移的乳腺癌患者诊断中的临床价值。方法研究取样70例入院检查治疗的乳腺癌患者,其中骨转移患者30例为转移组,无骨转移患者40例为未转移组,分别接受CA15-3、TPS结合SPECT/CT核素骨显像诊断,评价3项指标单独与联合诊断的临床意义,并分析乳腺癌骨转移患者不同骨组织表观弥散系数(average diffusion coefficient,ADC值)。结果转移组的CA15-3、TPS水平130.22±73.11U/mL、165.77±60.22U/L高于未转移组30.44±5.89U/mL、80.56±10.22U/L,差异具有统计学意义(t=8.615、8.802,P<0.05);70例乳腺癌中,病理确诊发生骨转移30例,其中单发骨转移10例,多发骨转移20例,胸/锁骨7例,脊椎10例,肋骨5例,骨盆8例。CA15-3、TPS结合SPECT核素骨显像联合检测诊断的灵敏度、特异性、准确度高于3种方法单独检测诊断结果(P<0.05);胸/锁骨、脊椎、肋骨、骨盆转移病灶ADC值水平与正常骨组织相比组间差异具有统计学意义(P<0.05)。结论CA15-3、TPS结合SPECT/CT核素骨显像用于乳腺癌骨转移疾病诊断中,可提高诊断准确率与灵敏度,临床意义显著。Objective To explore the diagnostic value of serum carbohydrate antigen 15-3(CA15-3)level,serum tissue polypeptide specific antigen(TPS)level and SPECT/CT radionuclide bone imaging in patients with bone metastases from breast cancer.Methods 70 patients with breast cancer who were hospitalized for the examination and treatment were sampled for this study,including 30 patients with bone metastasis as observation group A,40 patients without bone metastasis as observation group B,and 70 healthy people who were hospitalized for physical examination during the same period as the control group.All subjects were diagnosed by CA15-3 and TPS combined with SPECT radionuclide bone imaging,respectively,and the clinical significance of the individual and combined diagnosis of the three indicators was evaluated.Results Levels of CA15-3 and TPS in group A were significantly higher than those in group B and control group(P<0.05);Among 70 cases of breast cancer,30 cases of bone metastasis were pathologically confirmed,including 10 cases of single bone metastasis,20 cases of multiple bone metastasis,7 cases of chest/clavicle,10 cases of spine,5 cases of ribs and 8 cases of pelvis.The sensitivity,specificity and accuracy of CA15-3,TPS combined with SPECT radionuclide bone imaging were higher than those of single-marker tests(P<0.05);Compared with normal bone tissue,ADC values of metastatic lesions in chest/clavicle,spine,ribs and pelvis were significantly different between groups(P<0.05).Conclusion CA15-3,TPS combined with SPECT radionuclide bone imaging in the diagnosis of bone metastasis of breast cancer can improve the diagnostic accuracy and sensitivity,with a significant clinical significance.

关 键 词：乳腺癌骨转移 SPECT/CT核素骨显像 血清糖链抗原153 血清组织多肽特异性抗原 

分 类 号：R737.9[医药卫生—肿瘤]