结直肠癌组织上皮膜蛋白1、ETS变异转录因子4与临床病理特征和预后的关系研究  

Study on the Relationship between Epithelial Membrane Protein 1 and ETS Variant Transcription Factor 4 in Colorectal Cancer Tissues and Clinicopathological Features and Prognosis

作　　者：张株惠 崔国策 姚玲 李莹倩 袁润 李华山[1] ZHANG Zhu-hui;CUI Guo-ce;YAO Ling;LI Ying-qian;YUAN Run;LI Hua-shan(Department of Anorectal,Guang'anmen Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing,100053,China;Department of Surgery,Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing,100038,China;Department of Anorectal,Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing,100091,China;Department of Anorectal,The Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine,Beijing,100029,China)

机构地区：[1]中国中医科学院广安门医院肛肠科,北京100053 [2]首都医科大学附属北京世纪坛医院外科,北京100038 [3]中国中医科学院西苑医院肛肠科,北京100091 [4]北京中医药大学第三附属医院肛肠科,北京100029

出　　处：《现代生物医学进展》2024年第23期4455-4457,4460,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金面上项目(81673980)。

摘　　要：目的:探讨结直肠癌(CRC)组织上皮膜蛋白1(EMP1)、ETS变异转录因子4(ETV4)与临床病理特征和预后的关系。方法:收集180例CRC患者术中切除的CRC组织及癌旁组织,对比不同组织中EMP1、ETV4阳性表达率,并分析二者与CRC患者临床病理特征的关系。根据CRC患者EMP1、ETV4阳性表达情况将其分为EMP1、ETV4阳/阴性组,随访3年,采用Kaplan-Meier生存曲线分析3年总生存率;采用多因素Cox回归分析影响因素。结果:CRC组织中EMP1阳性表达率为36.11%,低于癌旁组织,ETV4阳性表达率为61.11%,高于癌旁组织(P<0.05)。EMP1、ETV4表达与淋巴结转移、分化程度、TNM分期有关(P<0.05)。随访3年,失访3例,CRC患者3年总生存率为71.75%(127/177)。EMP1阳性组的3年总生存率高于阴性组(P<0.05);ETV4阳性组的3年总生存率低于阴性组(P<0.05)。有淋巴结转移、TNMⅢ期、EMP1阴性、低分化、ETV4阳性为CRC患者预后不良的危险因素(P<0.05)。结论:CRC组织中EMP1阳性表达率降低,ETV4阳性表达率升高,二者与CRC患者分化程度、TNM分期、淋巴结转移及预后不良密切相关。Objective:To investigate the relationship between epithelial membrane protein 1(EMP1),ETS variant transcription factor 4(ETV4)and clinicopathological features and prognosis in colorectal cancer(CRC)tissues.Methods:CRC tissues and adjacent tissues of 180 CRC patients were collected,the positive expression rates of EMP1 and ETV4 in different tissues were compared,and the relationship between the two and clinicopathological features of CRC patients were analyzed.CRC patients were divided into EMP1 and ETV4 positive/negative groups based on their EMP1 and ETV4 positive expression,3 years after follow-up,the 3-year overall survival rate were analyzed by Kaplan-Meier survival curve.The influencing factors were analyzed by Multivariate Cox regression analysis.Results:The positive expression rate of EMP1 in CRC tissues was 36.11%,which was lower than that in adjacent tissues.The positive expression rate of ETV4 was 61.11%,which was higher than that in adjacent tissues(P<0.05).The expression of EMP1 and ETV4 were related to the lymph node metastasis,degree of differentiation and TNM stage(P<0.05).During a 3 years after follow-up,3 cases were lost to follow-up,the 3-year overall survival rate of CRC patients was 71.75%(127/177).The 3-year overall survival rate of EMP1 positive group was higher than that of EMP1 negative group(P<0.05).The 3-year overall survival rate of ETV4 positive group was lower than that of ETV4 negative group(P<0.05).Lymph node metastasis,TNM stage III,EMP1 negative,poor differentiation and ETV4 positive were risk factors for poor prognosis in CRC patients(P<0.05).Conclusion:The rate of EMP1 positive expression decreased and ETV4 positive expression increased in CRC tissues,which are closely related to the differentiation degree of differentiation,TNM stage,lymph node metastasis and poor prognosis in CRC patients.

关 键 词：结直肠癌 上皮膜蛋白1 ETS变异转录因子4 病理特征 预后 

分 类 号：R735.35[医药卫生—肿瘤]