息肉状脉络膜血管病变抗VEGF治疗前后细胞因子的变化及近远期预后影响因素分析  

Changes in Cytokines before and after anti-VEGF Treatment for Polypoid Choroidal Vascular Disease and Analysis of Factors Affecting Short-term and Long-term Prognosis

作　　者：刘琪[1] 王晓虹[1] 谢小东[1] 丁琳[1] 蒋晨[1] LIU Qi;WANG Xiao-hong;XIE Xiao-dong;DING Lin;JIANG Chen(Department of Ophthalmology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang,830001,China)

机构地区：[1]新疆维吾尔自治区人民医院眼科,新疆乌鲁木齐830001

出　　处：《现代生物医学进展》2024年第23期4516-4518,4538,共4页Progress in Modern Biomedicine

基　　金：2021年新疆维吾尔自治区人民医院院内项目(20210112);2022年新疆维吾尔自治区自然科学基金面上项目(2022D01C134)。

摘　　要：目的:探讨息肉状脉络膜血管病变抗血管内皮生长因子(VEGF)治疗前后细胞因子的变化及近远期预后影响因素。方法:选取2020.1-2023.1收治的86例息肉状脉络膜血管病变患者,均采取抗VEGF治疗,随访12个月,对比相关指标。依照随访结果分为近期BCVA提高组、近期BCVA未提高组及远期BCVA提高组、远期BCVA未提高组,进行因素分析。结果:治疗后12个月VEGF、bFGF、IL-6、IL-8、VCAM低于治疗前及治疗后3个月,IL-10高于治疗前及治疗后3个月(P<0.05);治疗后12个月BCVA、CRT均低于治疗前及治疗后3个月(P<0.05);病程、GLD、bFGF、IL-6、IL-8、IL-10、VCAM为息肉状脉络膜血管病变抗变VEGF治疗远期预后独立影响因素(P<0.05)。结论:针对息肉状脉络膜血管病变患者采取抗VEGF治疗可改善其视力水平与CRT厚度,治疗前后房水中VEGF、bFGF、IL-6、IL-8、IL-10、VCAM相关细胞因子浓度可发生变化,且上述细胞因子可为息肉状脉络膜血管病变近远期预后预测提供重要参考价值。Objective:To investigate the changes in cytokines before and after treatment with anti vascular endothelial growth factor(VEGF)in polypoid choroidal vascular lesions,as well as the factors affecting short-term and long-term prognosis.Methods:86 patients with polypoidal choroidal vascular lesions admitted to 2020.1-2023.1 were selected and treated with anti-VEGF and followed up for 12 months to compare relevant indicators.According to the follow-up results,the factors were divided into groups with recent BCVA,short-term BCVA,long-term BCVA and long-term BCVA.Results:VEGF,bFGF,IL-6,IL-8 and VCAM were lower than before and 3 months after treatment,IL-10 was higher than before and 3 months after treatment(P<0.05);BCVA and CRT were lower than 12 months after treatment(P<0.05);disease duration,GLD,bFGF,IL,IL-6,IL-8,IL-10 and VCAM were independent factors of long-term prognosis of polyp choroidal vasculopathy with anti-variable VE GF treatment(P<0.05).Conclusion:Anti VEGF treatment for patients with polypoid choroidal vasculopathy can improve their visual acuity and CRT thickness.The concentrations of VEGF,bFGF,IL-6,IL-8,IL-10,and VCAM related cytokines in aqueous humor can undergo significant changes before and after treatment,and these cytokines can provide important reference value for predicting the short-and long-term prognosis of polypoid choroidal vasculopathy.

关 键 词：息肉状脉络膜血管病变 细胞因子 血管内皮生长因子 近远期预后 影响因素 

分 类 号：R774[医药卫生—眼科]