弥漫性大B细胞淋巴瘤患者循环肿瘤DNA与PET-CT基线肿瘤参数动态变化及相关性研究  

Dynamic Changes and Correlation between Circulating Tumor DNA and Tumor Parameters of PET-CT at Baseline in Patients with Diffuse Large B-cell Lymphoma

作　　者：郎涛[1] 李雪国 翟顺生 王如民 徐艳芳 古再丽努尔·吾甫尔[1] LANG Tao;LI Xue-guo;ZHAI Shun-sheng;WANG Ru-min;XU Yan-fang;Guzailinur·Wufur(Department of Hematology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang,830001,China)

机构地区：[1]新疆维吾尔自治区人民医院血液病科,新疆乌鲁木齐830001

出　　处：《现代生物医学进展》2024年第23期4549-4551,4591,共4页Progress in Modern Biomedicine

基　　金：新疆维吾尔自治区自然科学基金项目(2020D01C093)。

摘　　要：目的:研究弥漫性大B细胞淋巴瘤患者的ctDNA与PET-CT基线肿瘤参数动态变化以及相关性。方法:将2020.1~2022.2血液科诊治的63例弥漫性大B细胞淋巴瘤患者为观察组,同期22例非肿瘤患者患者为对照组,测定并比较相关指标,并分析相关性。结果:观察组患者的ctDNA、SUVmax、SUVmean、TMTV、TLG高于对照组患者(P<0.05);观察组内ctDNA、SUVmax、SUVmean、TMTV、TLG在Ann-Arbor分期中逐渐上升,在不同治疗时间段中逐渐下降(P<0.05);Spearman相关性显示:cDNA与SUVmax、SUVmean、TMTV、TLG均呈正相关性(P<0.05)。结论:弥漫性大B细胞淋巴瘤患者的ctDNA、PET-CT基线肿瘤参数均随着Ann-Arbor分期的上升而升高,化疗疗程的增加而下降,且ctDNA与SUVmax、SUVmean、TMTV、TLG呈正相关性。Objective:The dynamics and correlation of ctDNA and PET-CT baseline tumor parameters in patients with diffuse large B-cell lymphoma.Methods:63 patients with diffuse large B cell lymphoma treated by hematology department from 2020.1 to 2022.2 were in the observation group,and 22 non-tumor patients were in the matched group.Relevant indicators were determined and compared,and the correlation was analyzed.Result:The ctDNA,SUVmax,SUVmean,TMTV,and TLG were higher than those in the observation group(P<0.05);ctDNA,SUVmax,SUVmean,TMTV,TLG gradually increased in Ann-Arbor stage and decreased in different treatment periods(P<0.05);Spearman correlation showed positive cDNA with SUVmax,SUVmean,TMTV,and TLG(P<0.05).Conclusion:The baseline tumor parameters of ctDNA and PET-CT in patients with diffuse large B-cell lymphoma increase with the increase of Ann Arbor stage,while decrease with the increase of chemotherapy course.ctDNA is positively correlated with SUVmax,SUVmean,TMTV,TLG.

关 键 词：弥漫性大B细胞淋巴瘤 循环肿瘤DNA 正电子发射计算机断层显像 

分 类 号：R733.4[医药卫生—肿瘤]