Digestive enzymes inhibition, antioxidant and antiglycation activities of phenolic compounds from jabuticaba (Plinia cauliflora) peel  

作　　者：Larissa Lorrane Rodrigues Borges Leandro Licursi de Oliveira Valdeir Viana Freitas Bruno Ricardo de Castro Leite Júnior Amanda Lais Alves Almeida Nascimento Gabriel Abranches Dias Castro Sergio Antonio Fernandes Paulo César Stringheta 

机构地区：[1]Universidade Federal de Viçosa,Department of Food Technology,Avenida Peter Henry Rolfs,s/n,Viçosa,MG,36570-900,Brazil [2]Universidade Federal de Viçosa,Department of General Biology,Avenida Peter Henry Rolfs,s/n,Viçosa,MG,36570-900,Brazil [3]Universidade Federal de Viçosa,Department of Chemistry,Avenida Peter Henry Rolfs,s/n,Viçosa,MG,36570-900,Brazil

出　　处：《Food Bioscience》2022年第6期1933-1940,共8页食品生物科学（英文）

基　　金：We gratefully acknowledge Coordenaç˜ao de Aperfeiçoamento de Pessoal de Nível Superior(CAPES,Finance Code 001)-Brazil,Conselho Nacional de Desenvolvimento Científico e Tecnol´ogico(CNPq)-Brazil and Fundaç˜ao de Amparo`a Pesquisa do Estado de Minas Gerais(FAPEMIG)-Brazil for financial support;Bioclin,for the donation of kits for analyses.PCS,LLO,BRCLJ,and SAF are supported by Research Fellowships from CNPq.

摘　　要：In this study, jabuticaba peel purified phenolic extracts were studied regarding their potential inhibitory effects on digestive enzymes linked to diabetes mellitus (DM) and obesity, inhibitory activities towards glycation of bovine serum albumin (BSA), and antioxidant activities. The impact of in vitro gastrointestinal digestion (GID) on the stability of anthocyanins and bioactivities was also evaluated. The analyzed extracts exhibited significant inhibitory activities of α-glucosidase (IC_(50): 0.47–5.20 mg/mL), α-amylase (IC_(50): 0.45–1.88 mg/mL), and lipase (IC_(50): 13.52–111.51 mg/mL). The extracts also inhibited the glycation of BSA (IC50: 0.23–7.07 mg/mL) and showed relevant antioxidant activities. The correlation analysis indicated anthocyanins as one of the main contributing compounds to the bioactivities studied. Cyanidin-3-glucoside was the major anthocyanin identified in the extracts by HPLC analysis. After GID, there was a decrease in the total anthocyanin content (72.77% ± 1.67%) and, consequently, a reduction in the inhibitory activities of carbohydrate digestive enzymes and BSA glycation. This research provided scientific data about the functional properties of jabuticaba peel extracts, which may be a source of dietary compounds with hypoglycaemic, antiglycation, and antioxidant effects.

关 键 词：POLYPHENOLS Diabetes mellitus GLUCOSIDASE AMYLASE AGES 

分 类 号：TS201.2[轻工技术与工程—食品科学]