柴胡疏肝散加减联合丁苯酞胶囊治疗脑卒中后抑郁临床研究  

Clinical Study on Modified Chaihu Shugan Powder Combined with Butylphthalide Capsules for Post-Stroke Depression

作　　者：黄赛芳 周未莹[2] HUANG Saifang;ZHOU Weiying(Neurological Department,Yongjia Hospital of Traditional Chinese Medicine,Yongjia Zhejiang 325100,China;Neurological Department,Xinhua Hospital of Zhejiang Province,Hangzhou Zhejiang 310000,China)

机构地区：[1]永嘉县中医医院神经内科,浙江永嘉325100 [2]浙江省新华医院神经内科,浙江杭州310000

出　　处：《新中医》2024年第24期7-10,共4页New Chinese Medicine

基　　金：温州市医药卫生科研项目(Z2022017)。

摘　　要：目的:观察柴胡疏肝散加减联合丁苯酞胶囊治疗脑卒中后抑郁(PSD)的临床疗效及对血清神经生化标志物(S100B蛋白)水平的影响。方法:选取2021年1月1日—2023年11月30日永嘉县中医医院收治的62例PSD患者作为研究对象,按照随机数字表法分为2组各31例,对照组采用丁苯酞胶囊治疗,观察组在对照组治疗方案的基础上联合柴胡疏肝散加减治疗,2组均治疗20 d为1个疗程,持续治疗3个疗程。比较2组疗效,检测并比较2组治疗前、治疗1个疗程、治疗2个疗程、治疗3个疗程后的血清S100B蛋白变化情况;比较2组治疗前后汉密尔顿抑郁量表(HAMD)、美国国立卫生研究院卒中量表(NIHSS)评分,比较2组不良反应量表(TESS)评分。结果:治疗1个疗程、治疗2个疗程、治疗3个疗程后,2组各期血清S100B蛋白均较治疗前降低,观察组各期血清S100B均低于对照组,差异均有统计学意义(P<0.05)。治疗3个疗程后,2组HAMD、NIHSS评分均较治疗前降低,观察组HAMD、NIHSS评分均低于对照组,差异均有统计学意义(P<0.05)。观察组总有效率90.32%,高于对照组61.29%,差异有统计学意义(P<0.05)。治疗1个疗程、治疗2个疗程、治疗3个疗程后,观察组各期TESS评分均低于对照组,差异均有统计学意义(P<0.05)。结论:柴胡疏肝散加减联合丁苯酞胶囊治疗脑卒中后抑郁,可降低血清S100B蛋白水平,改善抑郁症状,临床疗效良好,具有一定安全性。Objective:To observe the clinical effect of modified Chaihu Shugan Powder combined with Butylphthalide Capsules for post-stroke depression(PSD)and its effect on levels of neurobiochemical markers(S100B protein)in serum.Methods:A total of 62 PSD patients in Yongjia Hospital of Traditional Chinese Medicine form January 1,2021 to November 30,2023 were selected as the research subjects and randomly divided into two groups of 31 each according to the random number table method.The control group was treated with Butylphthalide Capsules,and the observation group was treated with Chaihu Shugan Powder in addition to the control group's treatment plan.Both groups were treated for three courses,with 20 days being one course of treatment.Compared the clinical effects in the two groups.Measured and compared the changes in serum S100B protein levels before treatment,and after one course of treatment,and two and three courses of treatment.Compared the scores of Hamilton Depression Scale(HAMD)and National Institutes of Health Stroke Scale(NIHSS)before and after treatment between the two groups.Compared the Treatment-Emergent Symptom Scale(TESS)scores between the two groups.Results:After one course of treatment,and two and three courses of treatment,the serum S100B protein levels in both groups were decreased when compared with those before treatment,and the serum S100B levels in the observation group were lower than those in the control group at all stages,differences being significant(P<0.05).After three courses of treatment,the HAMD and NIHSS scores in both groups were decreased when compared with those before treatment,and the HAMD and NIHSS scores in the observation group were lower than those in the control group,differences being significant(P<0.05).The total effective rate was 90.32%in the observation group,which was higher than that of 61.29%in the control group,the difference being significant(P<0.05).After one course of treatment,and two and three courses of treatment,the TESS scores in the observation group in each st

关 键 词：脑卒中后抑郁 柴胡疏肝散 丁苯酞胶囊 S100B蛋白 汉密尔顿抑郁量表 美国国立卫生研究院卒中量表 不良反应量表 

分 类 号：R749.4[医药卫生—神经病学与精神病学]