卵巢恶性肿瘤的发病与生殖因素的关系  

Relationship between the incidence of ovarian malignant tumors and reproductive factors

作　　者：陈雅茹 CHEN Yaru(Gynecological Oncology,The First Affiliated Hospital of Bengbu Medical University,Bengbu 233000,China)

机构地区：[1]蚌埠医科大学第一附属医院肿瘤妇科,安徽蚌埠233000

出　　处：《中国处方药》2024年第12期188-191,共4页Journal of China Prescription Drug

摘　　要：目的研究卵巢恶性肿瘤的发病与生殖因素之间的关系,为卵巢恶性肿瘤的早期筛查及预防提供明确的依据。方法从病历系统中查找2018年1月~2023年8月在蚌埠医学院第一附属医院就诊的且病理诊断为卵巢恶性肿瘤的患者,随机抽取200例作为观察组,并从体检中心随机抽取同期行健康体检的且结果无异常的健康女性200例作为对照组。收集两组对象的就诊时的年龄、月经初潮年龄、月经是否规则、月经周期、经期、是否痛经、孕次、生产次数及流产次数,进行回顾性研究和单因素与多因素Logistic回归分析。结果单因素分析显示,两组年龄、月经初潮年龄、经期、月经周期、生产次数、流产次数、是否痛经差异有统计学意义(P<0.05),而月经是否规律的差异无统计学意义(P>0.05)。多因素Logistic回归分析显示,初潮年龄、经期、痛经为影响卵巢恶性肿瘤发病的独立保护因素,而年龄,生产次数及月经周期为卵巢恶性肿瘤发生的危险因素。结论初潮年龄较大(晚于正常年龄)和经期较短的女性,卵巢恶性肿瘤发病风险较低,而年龄较大、生产次数较多和月经周期较长的女性,卵巢恶性肿瘤发病风险较高。建议对具有上述危险因素的女性进行定期的卵巢健康检查和监测,以便及时发现和治疗卵巢恶性肿瘤。Objective To explore the relationship between the incidence of ovarian malignant tumors and reproductive factors,providing a clear basis for the early screening and prevention of ovarian malignant tumors.Methods From the medical record system,200 patients with ovarian malignant tumors diagnosed by pathology in the First Affiliated Hospital of Bengbu Medical College from January 2018 to August 2023 were randomly selected as the observation group.Additionally,200 healthy women who underwent physical examination at the same time and had no abnormal result were randomly selected from the physical examination center as the control group.The age,age of menarche,menstrual regularity,menstrual cycle,menstrual period,dysmenorrhea,gravidity,number of births and number of abortions of the two groups were collected for retrospective study and univariate and multivariate Logistic regression analysis.Results Univariate analysis showed that there were significant differences in age,age of menarche,menstrual period,menstrual cycle,number of births,number of abortions,and dysmenorrhea between the two groups(P<0.05).Multivariate Logistic regression analysis showed that menarche age,menstrual period and dysmenorrhea were independent protective factors affecting the incidence of ovarian malignant tumors,while age,number of births and menstrual cycle were risk factors for ovarian cancer..Conclusion Women with older menarche age(later than normal age)and shorter menstrual period have a lower risk of ovarian malignant tumor,while women with older age,more production times and longer menstrual cycle have a higher risk of ovarian malignant tumor.It is recommended to carry out regular ovarian health examination and monitoring for women with the above risk factors in order to detect and treat ovarian malignant tumors in time.

关 键 词：卵巢恶性肿瘤 发病机制 保护因素 危险因素 生殖因素 

分 类 号：R737.31[医药卫生—肿瘤]