不同光照时长对康复期精神分裂症患者精神症状和认知功能的影响  

Effects of varying length of light therapy on psychiatric symptoms and cognitive functions of schizophrenia patients in the recovery phase

作　　者：蒲晓春[1] 谭庙琴[1] 曾汶琪 向美燕 雷娅辉[2] PU Xiaochun;TAN Miaoqin;ZENG Wenqi(Department of Psychiatry and Psychology,Nanfang Hospital,Southern Medical University,Guangdong,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院精神心理科,广州市510515 [2]南方医科大学南方医院健康管理科

出　　处：《河北医药》2024年第24期3812-3816,3820,共6页Hebei Medical Journal

基　　金：南方医科大学南方医院院长基金项目(编号:2022H008)。

摘　　要：目的评价不同光照时长对康复期精神分裂症患者的临床疗效和安全性。方法将164例康复期精神分裂症患者按照随机数字表法分为试验1组(n=43)、试验2组(n=39)、试验3组(n=37)和对照组(n=45)。对照组给予常规护理,其余3组在常规护理基础上给予光照治疗;试验1组每天光照时长30 min,试验2组60 min,试验3组90 min。采用阳性与阴性症状量表(PANSS)和MATRICS共识认知成套测试(MCCB)评价干预效果。结果治疗1个月,试验1组、试验2组和试验3组阴性症状、一般精神病理得分、症状总分低于对照组(P>0.05)(P<0.05);试验2组、试验3组上述得分又低于试验1组,差异有统计学意义(P<0.05)。试验1组、试验2组和试验3组注意/警觉性、信息处理速度、工作记忆、推理和问题解决、社会认知等维度得分和认知总分高于对照组(P<0.05);试验2组、试验3组上述得分又高于试验1组,差异有统计学意义(P<0.05)。结论光照60 min和90 min对康复期精神分裂症患者精神症状和认知功能改善作用优于30 min,但60 min和90 min疗效差异不明显,光照60 min可作为康复期精神分裂症的最佳治疗时长。Objective To evaluate the clinical efficacy and safety of varying length of light therapy on schizophrenia in the recovery phase.Methods A total of 164 schizophrenia patients in the recovery phase were randomly divided into the experimental 1 group(43 cases),experimental 2 group(39 cases),experimental 3 group(37 cases)and control group(45 cases).The control group was given routine nursing,and other three groups were implemented with light therapy at varying length(30min,60min and 90min in the experimental 1,2 and 3 groups,respectively).The clinical efficacy was assessed by grading the Positive and Negative Syndrome Scale(PANSS)and MATRICS consensus cognitive battery(MCCB).Results After 1 month of treatment,the negative symptoms,general psychopathology dimension scores and total psychiatric scores in the experimental 1 group,experimental 2 group and experimental 3 group were significantly lower than those of the control group(P<0.05).Meanwhile,the scores mentioned above in the experimental 2 group and experimental 3 group were significantly lower than those of the experimental 1 group(P<0.05).The scores of dimensions of attention/alertness,information processing speed,working memory,reasoning and problem solving,and social cognition and the total cognitive score of the experimental 1,2 and 3 groups were significantly higher than those of the control group(P<0.05),and they were significantly higher in the experimental 2 and 3 groups than the experimental 1 group(P<0.05).Conclusion Light therapy for 60 minutes and 90 minutes are better than 30 minutes in improving the mental symptoms and cognitive functions of patients with schizophrenia in the recovery phase.However,the efficacy is comparable between 60 minutes and 90 minutes.Light therapy for 60 minutes is the optimal to treat schizophrenia in the recovery phase.

关 键 词：光照疗法 精神分裂症 康复期 精神症状 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]