线粒体稳态失衡和功能障碍在抑郁症发病机制中的作用  

The role of mitochondrial homeostasis imbalance and dysfunction in the pathogenesis of depression

作　　者：谢银平 司璐佳 葛海龙 李晨[2] 黄俊洁 王雷敏 肖玲[1] 王高华[1] Xie Yinping;Si Lujia;Ge Hailong;Li Chen;Huang Junjie;Wang Leimin;Xiao Ling;Wang Gaohua(Institute of Neuropsychiatry,Renmin Hospital of Wuhan University,Wuhan430060,China;Department of Psychiatry,Renmin Hospital of Wuhan University,Wuhan430060,China;School of Automation,China University of Geosciences(Wuhan),Wuhan430074,China)

机构地区：[1]武汉大学人民医院湖北省神经精神病研究所,武汉430060 [2]武汉大学人民医院精神科,武汉430060 [3]中国地质大学(武汉)自动化学院,武汉430074

出　　处：《中华精神科杂志》2024年第12期808-813,共6页Chinese Journal of Psychiatry

基　　金：中央高校基本科研业务费专项资金(2042022kf1101);国家自然科学基金(82071523);武汉大学腾飞计划(TFLC2018001);湖北省重点研发项目(2020BCA064)。

摘　　要：抑郁症是一种高致残率和高自杀率的常见精神障碍, 其发病机制尚不清楚。大量研究表明抑郁症患者的能量代谢受损, 线粒体稳态(线粒体发生、线粒体融合与分裂、线粒体自噬)调控的关键基因表达改变, 线粒体功能障碍引发的三磷酸腺苷产生减少、活性氧应激、炎症等生物过程在抑郁症的发生发展中发挥重要作用, 但至今机制尚未明确, 且存在相互冲突的研究结果。本文从线粒体稳态失衡与功能障碍2个方面综述线粒体与抑郁症的内在关联及潜在机制, 并讨论了目前研究的局限性, 为了解抑郁症发病机制、开发靶向线粒体的新型治疗策略提供参考。Major depressive disorder is a common mental disorder with high rate of disability and suicide rate,but its pathogenesis remains unclear.Numerous studies indicate that energy metabolism is impaired in patients with depression,with the changes in the expression of critical genes that regulate mitochondrial homeostasis(mitochondrial biogenesis,fusion and fission,and mitophagy).Mitochondrial dysfunction,leading to reduced ATP production,oxidative stress,and inflammation,plays a significant role in the onset and development of depression,but the mechanism is still uncertain,and conflicting research findings exist.This paper reviews the intrinsic connections and potential mechanism between mitochondrial homeostasis imbalance,dysfunction,and depression,from two aspects:mitochondrial imbalance and dysfunction.It also discusses the limitations of current research,providing insight into understanding the pathogenesis of depression and developing novel mitochondrial-targeted therapeutic strategies.

关 键 词：抑郁症 线粒体稳态 线粒体功能障碍 ATP合成 氧化应激 炎症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]