缰核及其神经环路在抑郁症病理机制与抗抑郁治疗中的作用  

The role of the habenula and its neural circuitry in the pathological mechanism of depression and antidepressant treatment

作　　者：陈成凤 包乌优 李洁[2] 张宾 Chen Chengfeng;Bao Wuyou;Li Jie;Zhang Bin(Department of Psychiatry,the Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou 510370,China;Department of Psychiatry,Tianjin Anding Hospital,Tianjin Medical University,Tianjin 300222,China)

机构地区：[1]广州医科大学附属脑科医院精神科,广州510370 [2]天津市安定医院精神科天津医科大学,天津300222

出　　处：《中华精神科杂志》2024年第12期814-818,共5页Chinese Journal of Psychiatry

基　　金：天津市卫生健康科技项目(TJWJ2023MS038)。

摘　　要：缰核是一对位于间脑的微小脑结构, 起着连接前脑和中脑的枢纽作用, 能同时调节中脑多巴胺及5-羟色胺的释放。基础研究发现, 缰核在奖赏、厌恶、动机等生理功能中起着重要作用, 并可能参与抑郁症的发生机制。此外, 关于氯胺酮及深部脑刺激等抗抑郁治疗的研究表明, 缰核与抗抑郁疗效密切相关。本文系统阐述了缰核的体积、激活水平及其神经环路在抑郁症病理机制与抗抑郁治疗中的作用, 同时展望了靶向缰核的新疗法的前景。The habenula is a pair of tiny brain structures located in the diencephalon,serving as a hub connecting the forebrain and midbrain.It simultaneously regulates the release of dopamine and serotonin in the midbrain.Preclinical research has found that the habenula plays a significant role in physiological functions such as reward,aversion,and motivation,and may be involved in the pathogenesis of depression.Additionally,researches on antidepressant treatments such as ketamine and deep brain stimulation,have indicated that habenula is closely related to the efficacy of these therapies.This article systematically explains the role of the habenula′s volume,activation level,and its neural circuits in the pathological mechanism of depression and antidepressant treatments,while also exploring the prospects of novel therapies targeting the habenula.

关 键 词：抑郁症 缰核 神经环路 抗抑郁治疗 

分 类 号：R749.4[医药卫生—神经病学与精神病学]