雌激素波动与抑郁症的相关研究进展  

Research progress of the effect of estrogen fluctuation on depressive disorder

作　　者：何思怡 任中玉 肖玲 谢银平 王高华[1] He Siyi;Ren Zhongyu;Xiao Ling;Xie Yinping;Wang Gaohua(Department of Psychiatry,Renmin Hospital of Wuhan University,Wuhan 430060,China;The Institute of Neuropsychiatric Research of Hubei Province,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院精神科,武汉430060 [2]湖北省神经精神病研究所,武汉430060

出　　处：《中华精神科杂志》2024年第12期865-870,共6页Chinese Journal of Psychiatry

基　　金：国家自然科学基金(81871072, 82071523);武汉大学腾飞计划(TFLC2018001);湖北省重点研发项目(2020BCA064)。

摘　　要：抑郁症是常见的精神疾病之一, 主要表现为情绪低落、兴趣减退, 病情的发生发展受多方面因素影响和调控。科学研究和临床实践表明, 雌激素在抑郁症发病和进展过程中具有重要作用, 男女发病率从青春期开始出现性别差异, 并在更年期差异变大。本文对雌激素水平在抑郁症发病机制及治疗等方面的研究进展进行综述, 以期为抑郁症的发生发展机制研究及临床治疗提供方向。As one of the most common mental disorders,depressive disorder mainly manifests as depressed mood and loss of pleasure.The occurrence and development of depressive disorder are influenced and regulated by many factors.Scientific research and clinical practices have shown that estrogen plays a crucial role in the onset and progression of depressive disorder.From adolescence,estrogen fluctuation causes gender differences in the incidence of depressive disorder between male and female patients,and the differences become even more pronounced during menopause.This paper reviewed the research progress of estrogen levels in the pathogenesis and treatment of depressive disorder to provide new directions for further research on the mechanisms of occurrence and development and the clinical treatment of the disorder.

关 键 词：抑郁症 雌激素类 发病机制 治疗 

分 类 号：R749.4[医药卫生—神经病学与精神病学]