Identification of Cyprus propolis composition and evaluation of its antimicrobial and antiproliferative activities  

作　　者：Sual Tatlısulu Erkay Ozgor 

机构地区：[1]Department of Bioengineering,Faculty of Engineering,Cyprus International University,Cyprus [2]Department of Molecular Biology and Genetics,Faculty of Art and Science,Cyprus International University,Cyprus [3]Cyprus Bee and Bee Products Research Center,Cyprus International University,Cyprus

出　　处：《Food Bioscience》2023年第1期439-446,共8页食品生物科学（英文）

基　　金：funded by Cyprus International University(Grant number:2019-03).

摘　　要：Propolis is a raw natural product produced by Apis mellifera for hive defence.Scientists have also investigated propolis in terms of different biological activities such as antimicrobial and anticancer effects for many years.Its activities depend on the chemical composition of propolis and the composition is changed according to the botanical origin and sampling site.In this study,13 propolis samples were collected from different locations in Cyprus and ethanolic extraction of Cyprus Propolis(EECP)composition was analysed by GC-MS analysis.In total,there are 78 compounds were found in EECP.Three concentrations(200,100 and 50μg/ml)of EECP treated with breast cancer cell lines(MCF-7 and MDA-MB-231)at 24 h and 48 h for determined antiproliferation activity.All EECP,except EECP5 and EECP6,inhibit proliferation activity at all concentrations.Difference between exception samples and all others is the deficiency of 8-βH-cedran-8-ol.Three concentrations of EECP also treated with nosocomial bacteria and results showed EECPs prevented proliferation on Escherichia coli and Pseudomonas aeruginosa while no effect observed on Klebsiella pneumoniae.This situation might be due to the fact that K.pneumoniae is encapsulated.In conclusion,it has been determined that Cyprus propolis,which contains different active compounds,especially 8-βH-cedran-8-ol,is a potential product against infectious diseases and breast cancer proliferation.

关 键 词：PROPOLIS GC-MS MCF-7 MDA-MB-231 E.COLI P.Aeruginosa 

分 类 号：TS201.3[轻工技术与工程—食品科学]