The protective effect of 2’-Fucosyllactose on LPS-induced colitis suckling mice by ameliorating intestinal inflammation and modulating gut microbiota  

作　　者：Huiqing Lv Qianqian Li Zhennong Zhou Haoyi Fang Qixin Chen Yuying Shuai 

机构地区：[1]College of Pharmaceutical Science,Zhejiang Chinese Medical University,548 Binwen Road,310053,Hangzhou,Zhejiang,China

出　　处：《Food Bioscience》2023年第1期898-905,共8页食品生物科学（英文）

基　　金：supported by Zhejiang Provincial Natural Science Foundation of China(No.LY21C200002);the Nature Science Program of Zhejiang Chinese Medical University(No.2021JKZKTS026B).

摘　　要：2′-Fucosyllactose(2′-FL),the main component of human milk oligosaccharides(HMOs),has been shown to prevent intestinal diseases and its underlying mechanism remains unclear.The protective effect of 2′-FL against lipopolysaccharide(LPS)-induced colitis in suckling mice model was investigated by attenuating intestinal inflammation and modulating gut microbiota in the present study.2′-FL supplementation significantly ameliorated loss in body weight,diarrhea score and histological damage in colitis mice.2′-FL also reduced inflammatory infiltrates in colon epithelium,and IL-1βrelease in a dose-dependent manner.16S rRNA gene sequencing results showed that 2′-FL improved the gut microbiota diversity and increased the Bacteroidetes/Firmicutes ratio.In particular,2′-FL dramatically increased the relative abundance of Bacteroides and Akkermansia.The abundance of Bifidobacterium and Faecalibacterium in high dose of 2′-FL group(FLH)was higher than that in low dose of 2′-FL group(FLL).Moreover,FLH treatment significantly elevated the content of total short-chain fatty acids that nearly reached its normal level,especially the levels of propionate and butyrate in the colonic fecal of colitis mice.2′-FL might be used as a promising dietary supplement to prevent intestinal disorders through suppressing intestinal inflammation and modulating gut microbiota.

关 键 词：2′-FL Acute colitis LPS Gut microbiota SCFAs 

分 类 号：R574[医药卫生—消化系统]