ASAP1与P53在卵巢高级别浆液性癌中的表达及意义  

Expression and Significance of ASAP1 and P53 in High-grade Serous Ovarian Carcinoma

作　　者：邹亮[1] 揭由坤[1] 郭琦 ZOU Liang;JIE Youkun;GUO Qi(Department of Pathology,Jiangxi Maternal and Child Health Hospital,Nanchang 330038,China;不详)

机构地区：[1]江西省妇幼保健院病理科,江西南昌330038

出　　处：《中国医学创新》2024年第36期157-161,共5页Medical Innovation of China

基　　金：江西省卫生健康委科技计划项目(202211127)。

摘　　要：目的:探讨二磷酸腺苷核糖化因子鸟苷酸激酶1(ASAP1)与P53在卵巢高级别浆液性癌(HGSOC)中的表达及临床病理意义。方法:收集2020年5月—2024年5月江西省妇幼保健院的108例卵巢浆液性肿瘤组织蜡块标本,根据病理类型分为四组,其中40例HGSOC为A组、28例卵巢低级别浆液性癌为B组、20例卵巢交界性浆液性肿瘤为C组、20例卵巢浆液性囊腺瘤为D组,运用免疫组化Elivision两步法检测所有组别中ASAP1和P53的表达,比较不同组别中ASAP1及P53的表达差异;并重点分析A组中ASAP1、P53表达与临床FIGO分期、淋巴结转移等临床病理特征的关系。结果:(1)A组ASAP1及P53阳性率均明显高于B组、C组及D组,差异均有统计学意义(P<0.05),B组中ASAP1阳性率明显高于C组及D组,差异均有统计学意义(P<0.05);(2)A组中淋巴结转移者ASAP1阳性率明显高于淋巴结无转移者,差异有统计学意义(P<0.05),FIGO Ⅲ、Ⅳ期者ASAP1阳性率明显高于FIGOⅠ、Ⅱ者,差异有统计学意义(P<0.05);(3)A组中ASAP1与P53表达呈正相关(P<0.01)。结论:ASAP1与P53在HGSOC的发生发展中起协同作用,ASAP1表达与HGSOC的临床FIGO分期、淋巴结转移有关,提示ASAP1可能是预测HGSOC生物学行为及预后的潜在指标。Objective:To investigate the expression and clinicopathological significance of adenosine diphosphate ribosylation factor guanylate kinase 1(ASAP1)and P53 in high-grade serous ovarian carcinoma(HGSOC).Method:A total of 108 cases of ovarian serous tumor tissue wax samples from May 2020 to May 2024 in Jiangxi Maternal and Child Health Hospital were collected and divided into four groups according to pathological types,including 40 cases of HGSOC as group A,28 cases of low-grade ovarian serous cancer as group B,20 cases of borderline ovarian serous tumor as group C,and 20 cases of ovarian serous cystadenoma as group D.The expression of ASAP1 and P53 in all groups was detected by immunohistochemical Elivision two-step method,and the expression differences of ASAP1 and P53 in different groups were compared.The relationship between the expression of ASAP1,P53 in group A and clinical FIGO stage,lymph node metastasis and other clinicopathological features was analyzed.Result:(1)The positive rates of ASAP1 and P53 in group A were significantly higher than those in group B,group C,and group D,the differences were statistically significant(P<0.05),the positive rate of ASAP1 in group B was significantly higher than that in group C and group D, the differences were statistically significant (P<0.05). (2) The positive rate of ASAP1 in patients with lymph node metastasis in group A was significantly higher than that in patients without lymph node metastasis, the difference was statistically significant (P<0.05). The positive rate of ASAP1 in patients with FIGO stage Ⅲ, Ⅳ was significantly higher than that in patients with FIGO stage Ⅰ, Ⅱ, the difference was statistically significant (P<0.05). (3) There is a positive correlation between ASAP1 and P53 expression in group A (P<0.01). Conclusion: ASAP1 and P53 play a synergistic role in the occurrence and development of HGSOC, the expression of ASAP1 is related to FIGO staging and lymph node metastasis of HGSOC, suggesting that ASAP1 may be a potential indicator for predict

关 键 词：卵巢高级别浆液性癌 二磷酸腺苷核糖化因子鸟苷酸激酶1 P53 

分 类 号：R737.31[医药卫生—肿瘤]