The Impact of SARS-CoV-2 on Liver Diseases and Potential Phytochemical Treatments  

作　　者：Dhanvee Balaji Ranjith Balakrishnan Dhasarathdev Srinivasan Rajasekaran Subbarayan Rupendra Shrestha Nityanand Srivastava Ankush Chauhan 

机构地区：[1]Centre for Advanced Biotherapeutics and Regenerative Medicine,Faculty of Research,Chettinad Hospital and Research Institute,Chettinad Academy of Research and Education,Kelambakkam,India [2]Centre for Herbal Pharmacology and Environmental Sustainability,Faculty of Allied Health Sciences,Chettinad Hospital and Research Institute,Chettinad Academy of Research and Education,Kelambakkam,India [3]Research and Collaboration,Anka Analytica,Melbourne,Australia [4]External Consultant,Independent Researcher,Pittsfield,Massachusetts,USA [5]Department of Cell Biology,Albert Einstein College of Medicine,New York,USA

出　　处：《Infectious Microbes & Diseases》2024年第4期177-188,共12页感染微生物与疾病（英文）

摘　　要：The COVID-19 pandemic,caused by the SARS-CoV-2 virus,has brought about numerous challenges.One of these challenges is the impact of SARS-CoV-2 on the liver.Although this virus primarily affects the lungs,it can induce elevated transaminase levels and the development of scar tissue in the liver,exacerbating preexisting liver conditions.Individuals with preexisting conditions,such as nonalcoholic fatty liver disease,alcohol-induced liver disease and hepatocellular carcinoma,face an increased risk of mortality from COVID19.However,drugs currently used to treat COVID-19 have undesirable side effects,which make them unsuitable for patients with preexisting liver conditions.In this review,we explore the potential of phytochemicals,such as apigenin,berberine,curcumin,epigallocatechin-3-gallate,quercetin,resveratrol and silymarin,for treatment of the liver conditions,including nonalcoholic fatty liver disease,alcohol-induced liver disease and hepatocellular carcinoma.We also discuss significant associations between phytochemicals and COVID-19 by depicting their molecular interactions.Based on the discussed overlapping functions,it is important to assess the therapeutic efficacy of phytochemicals that possess hepatoprotective properties as potential alternative treatments for COVID-19.

关 键 词：COVID-19 nonalcoholic fatty liver disease alcohol-induced liver injury hepatocellular carcinoma PHYTOCHEMICALS HEPATOPROTECTIVE 

分 类 号：R563.1[医药卫生—呼吸系统]