Modifiers of the Effects of Vitamin D Supplementation on Cardiometabolic Risk Factors:A Systematic Review and Meta-Analysis  

作　　者：Peng An Sitong Wan Langrun Wang Tiancheng Xu Teng Xu Yonghui Wang Jin Liu Keji Li Xifan Wang Jingjing He Simin Liu 

机构地区：[1]Food Laboratory of Zhongyuan,Luohe 462300,China [2]School of Food and Health,Beijing Technology&Business University,Beijing 100048,China [3]Institute of Environmental and Operational Medicine,Tianjin 300050,China [4]Systems Engineering Institute,Beijing 100010,China [5]Department of Nutrition and Food Hygiene,School of Public Health,Peking University,Beijing 100191,China [6]Department of Obstetrics and Gynecology,Columbia University,New York,NY 10032,USA [7]Center for Global Cardiometabolic Health,Departments of Epidemiology,Medicine,and Surgery,Brown University,Providence,RI 02912,USA

出　　处：《Engineering》2024年第11期99-107,共9页工程（英文）

基　　金：supported by the National Key Research and Development Program of China(2023YFF1105201);the China Dairy Industry Association Dairy Science and Technology Innovation Fund(CDIAKCJJ-MN-2023-001);the National High Level Hospital Clinical Research Funding(bj-2023-72);the 111 project from the Education Ministry of China(B18053).

摘　　要：The inconsistent findings concerning the effects of vitamin D supplementation on cardiometabolic risk factors and the large heterogeneity in the published literature call for further research to identify sources of heterogeneity and potential effect modifiers.We performed a meta-analysis of randomized controlled trials(RCTs)published until March 2024 that reported estimates for the effects of vitamin D supplementation on cardiometabolic factors and relevant baseline covariates of RCT participants.A total of 17656 participants from 99 RCTs were analyzed,and weighted mean differences(95%confidence intervals(CI))for the intervention status were derived using random-effects modeling.Overall,compared with the placebo,vitamin D supplementation(median dose:3320 international unit(IU)·day^(-1);range 40-120000 IU·day^(-1))had favorable effects on systolic blood pressure(SBP;-2.04(95%CI,-3.50,-0.59)mmHg;1 mmHg=0.133 kPa),diastolic blood pressure(DBP;-3.00(95%CI,-3.61,-2.39)mmHg),total cholesterol(TC;-0.12(95%CI,-0.21,-0.03)mmol·L^(-1)),fasting blood glucose(FBG;-0.13(95%CI,-0.20,-0.05)mmol·L^(-1)),hemoglobin A1C(A1C;-0.09%(95%CI,-0.13%,-0.05%)),and fasting blood insulin(FBI:-7.61(95%CI,-11.93,-3.30)pmol·L^(-1)).The benefits of vitamin D were most evident in trials performed in non-Westerners,participants with baseline 25-hydroxyvitamin D(25[OH]D)lower than 15.0 ng·mL^(-1),non-obese(body mass index(BMI)<30 kg·m^(-2)),and older(age-50 years).The findings of this study underscore the need for personalized vitamin D intervention strategies that comprehensively account for individual patient characteristics(such as ethnocultural background,age,BMI,and circulating 25[OH]D level),intervention dosage,and intervention duration to optimize cardiometabolic health outcomes.

关 键 词：Vitamin D Cardiometabolic risk factors META-ANALYSIS Ethnocultural differences OBESITY 

分 类 号：R54[医药卫生—心血管疾病]