整合素家族活化肝星状细胞的研究进展:抗肝纤维化的新靶点  

Research progress on integrins activating hepatic stellate cells:novel targets for anti-liver fibrosis

作　　者：刘林祥 朱萱[1] LIU Lin-Xiang;ZHU Xuan(Department of Gastroenterology,the First Affiliated Hospital of Nanchang University,the Jiangxi Institute of Gastroenterology and Hepatology,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院消化内科,江西省消化疾病研究所,南昌330006

出　　处：《生命科学》2024年第11期1360-1366,共7页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(82360131,819-60120);江西省研究生创新专项项目(YC2023-B058)。

摘　　要：肝纤维化是肝脏对各种慢性刺激做出的修复性反应,以大量细胞外基质在肝内沉积为特征。寻找肝纤维发生发展的关键靶点可为后续治疗肝纤维化提供有力依据。整合素是一种异二聚体细胞膜蛋白,其介导的细胞与胞外环境的相互作用调节多种生理和病理过程。越来越多证据表明,整合素介导的信号转导在多种慢性疾病,尤其是肝脏纤维化中发挥了关键的作用。现就整合素家族的特性进行简要概述,并重点关注其在活化肝星状细胞或调节肝纤维化发生发展中的具体机制。Liver fibrosis is a reparative response of the liver to various chronic stimuli,characterized by the deposition of a large amount of extracellular matrix within the liver.Identifying key targets in the occurrence and progression of liver fibrosis can provide a strong basis for subsequent therapeutic interventions.Integrins are a type of heterodimeric cell membrane proteins that mediate the interaction between cells and the extracellular environment to regulate various physiological and pathological processes.Increasing evidence suggests that integrin-mediated signaling plays a crucial role in multiple chronic diseases,particularly in liver fibrosis.This brief overview focuses on the characteristics of the integrin family and specifically highlights its involvement in the activation of hepatic stellate cells and the regulation of liver fibrosis occurrence and progression.

关 键 词：整合素 肝纤维化 肝星状细胞 信号通路 

分 类 号：Q485[生物学—生理学] R575[医药卫生—消化系统]