大剂量奥美拉唑联合奥曲肽治疗消化性溃疡并上消化道出血的临床效果  

Clinical effect of high-dose omeprazole combined with octreotide in the treatment of peptic ulcer complicated with upper gastrointestinal bleeding

作　　者：杜敏 王冬青 DU Min;WANG Dongqing(Gastroenterology Department,Fuping County Hospital,Weinan 711700,China;Digestive Endoscopy Center,Fuping County Hospital,Weinan 711700,China)

机构地区：[1]富平县医院消化内科,陕西渭南711700 [2]富平县医院消化内镜中心,陕西渭南711700

出　　处：《临床医学研究与实践》2024年第35期42-45,共4页Clinical Research and Practice

摘　　要：目的分析大剂量奥美拉唑联合奥曲肽治疗消化性溃疡并上消化道出血的临床效果。方法选取2020年1月至2022年12月我院收治的150例消化性溃疡并上消化道出血患者作为研究对象,以入院先后顺序将其分为对照组(75例,常规剂量奥美拉唑联合奥曲肽)和研究组(75例,大剂量奥美拉唑联合奥曲肽)。比较两组的治疗效果、凝血功能、免疫功能及临床指标。结果研究组的治疗总有效率显著高于对照组(P<0.05)。治疗后,研究组的纤维蛋白原水平高于对照组,D-二聚体、血管紧张素转化酶水平低于对照组,凝血酶原时间短于对照组(P<0.05)。治疗后,研究组的CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05)。治疗后,研究组的尿素氮、血肌酐水平低于对照组,胃酸pH值高于对照组(P<0.05)。结论大剂量奥美拉唑联合奥曲肽治疗消化性溃疡并上消化道出血有助于提高整体止血效果,改善机体免疫水平,促进患者康复,具有很高的应用价值。Objective To analyze the clinical effect of high-dose omeprazole combined with octreotide in the treatment of peptic ulcer complicated with upper gastrointestinal bleeding.Methods A total of 150 patients with peptic ulcer complicated with upper gastrointestinal bleeding admitted in our hospital from January 2020 to December 2022 were selected as the research objects.The patients were divided into control group(75 cases,conventional dose omeprazole combined with octreotide)and study group(75 cases,high dose omeprazole combined with octreotide)according to the order of admission.The therapeutic effect,coagulation function,immune function and clinical indexes of the two groups were compared.Results The total effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05).After treatment,the fibrinogen level in the study group was higher than that in the control group,the D-dimer and angiotensin converting enzyme levels were lower than those in the control group,and the prothrombin time was shorter than that in the control group(P<0.05).After treatment,the CD4^(+)and CD4^(+)/CD8^(+)in the study group were higher than those in the control group,and the CD8^(+)was lower than that in the control group(P<0.05).After treatment,the urea nitrogen and serum creatinine levels in the study group were lower than those in the control group,and the gastric acid pH value was higher than that in the control group(P<0.05).Conclusion High-dose omeprazole combined with octreotide in the treatment of peptic ulcer complicated with upper gastrointestinal bleeding is helpful to improve the overall hemostatic effect,improve the immune level of the body,and promote the rehabilitation of patients,which has high application value.

关 键 词：消化性溃疡 上消化道出血 奥美拉唑 

分 类 号：R573.2[医药卫生—消化系统]