脑小血管病内皮功能障碍的生物标志物研究进展  

Research progress on biomarkers of endothelial dysfunction in cerebral small vessel disease

作　　者：刘聪杰 肖艾妮 王翔宇[1] LIU Congjie;XIAO Aini;WANG Xiangyu(Neurological Department,the Third Clinical Medical School of China Three Gorges University/Sinopharm Gezhouba Central Hospital,Yichang 443000,China)

机构地区：[1]三峡大学第三临床医学院/国药葛洲坝中心医院神经内科,湖北宜昌443000

出　　处：《临床医学研究与实践》2024年第35期182-185,共4页Clinical Research and Practice

摘　　要：随着世界人口老龄化的加剧,脑小血管病(CSVD)发病率逐渐升高,对人们的生活和健康造成了极大威胁。该病隐匿,临床症状各异,易被忽略,同时缺乏有效的治疗手段。相关研究证明,内皮功能障碍参与了CSVD的发生与发展过程。本文旨在对CSVD的发病机制——内皮功能障碍的生物标志物进行综述,进一步探究CSVD的危险因素及其作用机制,为临床诊疗提供参考和新思路。With the aging of the world's population,the incidence of cerebral small vessel disease(CSVD)has gradually increased,posing a great threat to people's lives and health.The disease is hidden,has different clinical symptoms,and is easily ignored.At the same time,there is a lack of effective treatment.Relevant studies have proven that endothelial dysfunction is involved in the occurrence and development of CSVD.This article aims to review the pathogenesis of CSVD-biomarkers of endothelial dysfunction,further explore the risk factors of CSVD and its mechanism of action,and provide reference and new ideas for clinical diagnosis and treatment.

关 键 词：脑小血管病 内皮功能障碍 生物标志物 

分 类 号：R743.3[医药卫生—神经病学与精神病学]