热敏灸联合榄香烯及洛铂腹腔灌注治疗晚期卵巢癌继发恶性腹水的效果  

Effect of Heat Sensitive Moxibustion Combined with Peritoneal Infusion of Elemene and Lobaplatin on Malignant Ascites Secondary to Advanced Ovarian Cancer

作　　者：唐秋燕 石玲[1] 梅耀国 曾灵芝[1] 江波 段训凰[1] TANG Qiuyan;SHI Ling;MEI Yaoguo;ZENG Lingzhi;JIANG Bo;DUAN Xunhuang(Oncology Department,Jiujiang NO.1 People's Hospital,Jiujiang 332000,China;不详)

机构地区：[1]九江市第一人民医院肿瘤科,江西九江332000 [2]九江市中医医院肿瘤科,江西九江332000

出　　处：《中国医学创新》2024年第35期25-29,共5页Medical Innovation of China

基　　金：江西省中医药管理局科技计划项目(2022A163)

摘　　要：目的:探讨热敏灸联合榄香烯及洛铂腹腔灌注在晚期卵巢癌继发恶性腹水患者中的应用效果。方法:选择2018年1月—2022年1月九江市第一人民医院收治的60例晩期卵巢癌继发恶性腹水的老年患者。根据随机数字表法分为试验组及对照组,各30例。对照组接受榄香烯+洛铂腹腔灌注治疗,试验组在对照组基础上接受热敏灸治疗。比较两组腹水控制情况、血清肿瘤标志物水平及不良反应发生情况。结果:试验组腹腔积液客观缓解率为76.67%,高于对照组的40.00%,差异有统计学意义(P<0.05)。两组各项不良反应发生率比较,差异均无统计学意义(P>0.05)。治疗4周后,两组癌胚抗原、糖类抗原125、糖类抗原199均低于治疗前,且试验组均低于对照组,差异均有统计学意义(P<0.05)。结论:在榄香烯及洛铂腹腔灌注治疗的基础上增加热敏灸治疗,可进一步抑制老年晚期卵巢癌继发恶性腹水患者血清肿瘤标志物的表达,改善腹水情况,安全性高。Objective:To investigate the effect of heat sensitive moxibustion combined with peritoneal infusion of Elemene and Lobaplatin in patients with malignant ascites secondary to advanced ovarian cancer.Method:A total of 60 elderly patients with malignant ascites secondary to advanced ovarian cancer were selected from Jiujiang NO.1 People's Hospital from January 2018 to January 2022 were selected.They were divided into experimental group and control group according to the random number table method,with 30 cases in each group.The control group received Elemene and Lobaplatin peritoneal infusion treatment,and the experimental group received heat sensitive moxibustion treatment on the basis of the control group.The control of ascites,the levels of serum tumor markers and the occurrence of adverse reactions were compared between the two groups.Result:The objective remission rate of peritoneal effusion in experimental group was 76.67%,which was higher than 40.00%in control group,the difference was statistically significant(P<0.05).There were no significant differences in the incidence of adverse reactions between the two groups(P>0.05).After 4 weeks of treatment,carcinoembryonic antigen,carbohydrate antigen 125 and carbohydrate antigen 199 in two groups were lower than those before treatment,and those in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The addition of heat sensitive moxibustion on the basis of peritoneal infusion of Elemene and Lobaplatin can further inhibit the expression of serum tumor markers in elderly patients with secondary malignant ascites of advanced ovarian cancer,improve the condition of ascites,and have high safety.

关 键 词：热敏灸 榄香烯 洛铂 腹腔灌注 晚期卵巢癌 恶性腹水 

分 类 号：R737.31[医药卫生—肿瘤]