LEEP联合保妇康栓治疗宫颈上皮内瘤变合并HPV感染的临床效果  

Clinical effect of Baofukang suppository combined with loop electrosurgical excision procedure for treating patients with cervical intraepithelial neoplasia and human papillomavirus infection

作　　者：丁黎黎 徐海鸥 陈鑫 DING Lili;XU Haiou;CHEN Xin(The First People's Hospital of Chun'an County,Hangzhou,Zhejiang Province,311700;Zhejiang Provincial Hospital of Traditional Chinese Medicine,Hangzhou,Zhejiang Province)

机构地区：[1]浙江省淳安县第一人民医院,311700 [2]浙江省中医院

出　　处：《中国计划生育学杂志》2024年第12期2768-2772,共5页Chinese Journal of Family Planning

摘　　要：目的:探究保妇康栓联合宫颈电环切除术(LEEP)治疗宫颈上皮内瘤变(CIN)合并人乳头瘤病毒(HPV)感染的临床效果。方法:选取本院2019年1月-2023年6月收治的CIN合并HPV感染患者245例,随机号码表法分为联合组(n=123)和单一组(n=122),分别行保妇康栓联合LEEP治疗、单纯LEEP治疗。比较两组相关临床症状变化、治疗6个月后临床效果、HPV转阴情况、治疗前后机体免疫功能水平。结果:治疗后,联合组阴道出血量(8.5±2.1 ml)和排液量(10.4±3.4ml)均低于单一组(14.5±3.1ml、16.4±3.4ml),阴道出血(6.3±2.1d)、排液(7.3±2.2d)及宫颈创面愈合(4.3±1.2周)时间均短于单一组(8.3±2.1d、9.8±2.6d、5.4±1.3周),盆腔疼痛发生率(1.7%)低于单一组(15.4%),治疗6个月后CIN总治愈率(98.3%)、HPV总转阴率(83.9%)均高于单一组(87.2%、65.0%),两组免疫功能指标CD4^(+)、CD3^(+)、CD4^(+)/CD8^(+)均升高,CD8^(+)、CD4^(+)CD25^(+)CD127^(-)均下降,且联合组变化幅度大于单一组(均P<0.05)。结论:保妇康栓联合LEEP治疗CIN合并HPV感染可有效提高治疗效果,上调HPV转阴及CIN治愈概率,促进相关临床症状及免疫功能恢复。Objective:To explore the clinical effect of Baofukang suppository combined with loop electrosurgical excision procedure(LEEP)for treating patients with cervical intraepithelial neoplasia(CIN)and human papillomavirus(HPV)infection.Methods:245 patients with CIN and HPV infection were selected and were divided into observation group(n=123)and control group(n=122)by random number table method from January 2019 to June 2023.The patients in the observation group were treated with Baofukang suppository combined with LEEP,and the patients in the control group were treated with LEEP alone.The changes of the related clinical symptoms,the clinical effect and HPV negative conversion status after 6 months of treatment,and the immune function level before and after treatment of the patients were compared between the two groups.Results:After treatment,the vaginal bleeding volume(8.5±2.1 ml)and the discharge volume(10.4±3.4 ml)of the patients in the observation group were significantly lower than those(14.5±3.1 ml and 16.4±3.4 ml)of the patients in the control group.The time of vaginal bleeding(6.3±2.1d),the discharge time(7.3±2.2d)and the cervical wound healing time(4.3±1.2 weeks)of the patients in the observation group were significantly shorter than those(8.3±2.1d,9.8±2.6d and 5.4±1.3 weeks)of the patients in the control group.The incidence of the pelvic pain(1.7%)of the patients in the observation group was significantly lower than that(15.4%)of the patients in the control group.The total cure rate of CIN(98.3%)and the total negative conversion rate of HPV infection(83.9%)of the patients in the observation group after 6 months of treatment were significantly higher than those(87.2%and 65.0%)of the patients in the control group.After treatment,the levels of the immune function indexes,such as CD4^(+),CD3^(+)and CD4^(+)/CD8^(+)of the patients in the two groups had increased significantly,the levels of CD8^(+),CD4^(+),CD25^(+)and CD127^(-)of the patients in the two groups had decreased significantly,and the changes of

关 键 词：宫颈上皮内瘤变 人类乳头瘤病毒 保妇康栓 宫颈电环切除术 疗效 

分 类 号：R737.33[医药卫生—肿瘤]