血浆Romo1、CXCL1、USP7水平在子宫内膜癌早期诊断及预后评估中的价值  

Values of the levels of the plasma reactive oxygen species modulator 1,CXC chemokine ligand 1,and ubiquitin specific protease 7 of women for early diagnosing their endometrial cancer and for evaluating their prognosis

作　　者：张盟盟 梁艳霞 常凤 秦欢 ZHANG Mengmeng;LIANG Yanxia;CHANG Feng;QIN Huan(Zhangjiakou First Hospital,Hebei Province,075000;Dingzhou People's Hospital,Hebei Province)

机构地区：[1]河北省张家口市第一医院,075000 [2]河北省定州市人民医院

出　　处：《中国计划生育学杂志》2024年第12期2949-2954,2959,共7页Chinese Journal of Family Planning

摘　　要：目的:探究血浆活性氧调节因子1(Romo1)、CXC型趋化因子配体1(CXCL1)、泛素特异性蛋白酶7(USP7)在子宫内膜癌(EC)早期诊断及预后评估中的价值。方法:选取2019年4月-2021年4月本院手术治疗的EC患者172例为病例组,根据术后预后情况分为预后不良69例、预后良好103例;同期健康体检172例为对照组。酶联免疫吸附法检测血浆Romo1、CXCL1、USP7水平;利用Kaplan-Meier生存曲线分析Romo1、CXCL1、USP7表达水平与EC患者预后关系;利用COX风险回归模型对EC患者预后影响因素进行分析;绘制受试者工作特征(ROC)曲线分析血浆Romo1、CXCL1、USP7水平对EC患者早期诊断及预后预测的价值。结果:病例组血浆Romo1(331.18±34.52ng/L)、CXCL1(92.62±11.61pg/ml)、USP7(28.15±4.67ng/ml)水平均高于对照组(261.28±29.83ng/L、69.28±7.66 pg/ml、15.39±2.58ng/ml),且病例例组预后不良患者血浆Romo1、CXCL1、USP7水平均高于预后良好患者,随访病例组血浆Romo1、CXCL1、USP7高表达患者3年生存率(39.8%、43.2%、43.5%)均低于低表达患者(78.7%、74.7%、75.9%)(均P<0.05)。多因素COX风险回归模型分析显示,Romo1升高、CXCL1升高、USP7升高、FIGO分期为Ⅲ~Ⅳ期均为影响EC患者预后的危险因素(P<0.05);ROC分析,Romo1、CXCL1、USP7三者联合对EC早期诊断及预后预测的曲线下面积(0.865、0.900)升高(均P<0.05)。结论:EC患者血浆Romo1、CXCL1、USP7水平显著升高,且与预后有关,三者联合检测对EC早期诊断及术后预后评估价值较高。Objective:To investigate the values of the levels of the plasma reactive oxygen species modulator 1(Romol),CXC chemokine ligand 1(CXCL1),and ubiquitin specific protease 7(USP7)of women for early diagnosing their endometrial cancer(EC)and for evaluating their prognosis.Methods:From April 2019 to April 2021,172 women with EC who had undergone surgery treatment in the hospital were included in the study group,and according to the prognosis,these women were divided into 69 cases with poor prognosis in group A and 103 cases with good prognosis in group B.Another 172 healthy women who underwent physical examinations were selected in the control group.Enzyme linked immunosorbent assay(ELISA)was used to measure the plasma Romol,CXCLl,and USP7 levels.Kaplan-Meier survival curve was used to analyze the correlation between the expression levels of Romol,CXCL1,and USP7 of the women with EC and their prognosis.COX risk regression model was applied to analyze the factors affecting the prognosis of the women with EC,Receiver operator characteristic(ROC)curve was used to analyze the value of the levels of plasma Romol,CXCLl and USP7 of the women for early diagnosing their EC occurrence and predicting their prognosis of EC.Results:The levels of the plasma Romol(331.18±34.52 ng/L),CXCL1(92.62±11.61 pg/ml)and USP7(28.15±4.67 ng/ml)of the women in the study group were significantly higher than those(261.28±29.83 ng/L,69.28±7.66 pg/ml and 15.39±2.58 ng/ml)of the women in the control group.The levels of the plasma Romol,CXCLl and USP7 of the women in group A were significantly higher than those of the women in group B,In the study group,the 3-year survival rate of the women with the high levels of plasma Romol(39.8%),CXCL1(43.2%)or USP7(43.5%)was significantly lower than that(78.7%,74.7% or 75.9%)of the women with the low levels of Romol,CXCLl or USP7(all P<0.05).Multivariate COX risk regression model analysis showed that the increased levels of Romol,CXCL1 and USP7,and the FIGO stage II-IV of EC of the women were the risk facto

关 键 词：子宫内膜癌 活性氧调节因子1 CXC型趋化因子配体1 泛素特异性蛋白酶7 早期诊断 预后 预测价值 

分 类 号：R737.33[医药卫生—肿瘤]