奥曲肽联合常规药物治疗急性上消化道出血患者的效果  

Effects of Octreotide combined with conventional drugs in treatment of patients with acute upper gastrointestinal bleeding

作　　者：祁宁宁 QI Ningning(Department of Gastroenterology of the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000 Henan,China)

机构地区：[1]河南科技大学第一附属医院消化内科,河南洛阳471000

出　　处：《中国民康医学》2024年第24期32-34,41,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察奥曲肽联合常规药物治疗急性上消化道出血患者的效果。方法:回顾性分析2021年5月至2022年7月该院收治的316例急性上消化道出血患者的临床资料,按照治疗方法不同将其分为对照组和研究组各158例。两组均予以基础治疗,在此基础上,对照组予以常规药物(凝血酶+奥美拉唑钠)治疗,研究组在对照组基础上联合奥曲肽治疗。比较两组临床疗效,临床指标(止血时间、腹痛消失时间、粪便隐血试验转阴时间、住院时间)水平,治疗前后炎性指标[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)]、凝血功能指标[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)]水平,以及不良反应发生率。结果:研究组治疗总有效率为92.41%(146/158),高于对照组的74.05%(117/158),差异有统计学意义(P<0.05);研究组止血时间、腹痛消失时间、粪便隐血试验转阴时间、住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组TNF-α、hs-CRP水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组PT、APTT均短于治疗前,且研究组短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:奥曲肽联合常规药物治疗急性上消化道出血患者可提高治疗总有效率,改善临床指标、凝血功能指标水平,降低炎性指标水平,效果优于单纯常规药物治疗。Objective:To observe effects of Octreotide combined with conventional drugs in treatment of patients with acute upper gastrointestinal bleeding.Methods:The clinical data of 316 patients with acute upper gastrointestinal bleeding admitted to this hospital from May 2021 to July 2022 were retrospectively analyzed.According to different treatment methods,they were divided into control group and study group,158 cases in each.Both groups were given basic treatment.On this basis,the control group was treated with conventional drugs(Thrombin+Omeprazole sodium),while the study group was treated with Octreotide on the basis of that of the control group.The clinical efficacy,the clinical indicators(hemostasis time,abdominal pain disappearance time,fecal occult blood test negative conversion time,hospitalization time)levels,the inflammatory indicators[tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)]and coagulation function indicators[activated partial thromboplastin time(APTT),prothrombin time(PT)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 92.41%(146/158),which was higher than 74.05%(117/158)in the control group,and the difference was statistically significant(P<0.05).The hemostasis time,the abdominal pain disappearance time,fecal occult blood test negative conversion time and the hospitalization time in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of TNF-αand hs-CRP in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the PT and APTT in the two groups were shorter than those before the treatment,those in the study group were shorter than those in the control group,and the differences were statisticall

关 键 词：急性上消化道出血 奥曲肽 凝血酶 奥美拉唑钠 凝血功能 炎性指标 不良反应 

分 类 号：R573.2[医药卫生—消化系统]