射频消融术联合T X化疗方案治疗乳腺癌肝转移患者的效果  

Effects of radiofrequency ablation combined with TX chemotherapy in treatment of breast cancer patients with liver metastasis

作　　者：何华楠 冯校迅 赵军 HE Huanan;FENG Xiaoxun;ZHAO Jun(Department of Breast Surgery of Pingdingshan People’s Hospital No.1,Pingdingshan 467000 Henan,China)

机构地区：[1]平顶山市第一人民医院乳腺外科,河南平顶山467000

出　　处：《中国民康医学》2024年第24期35-37,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察射频消融术联合TX化疗方案治疗乳腺癌肝转移患者的效果。方法:选取2019年1月至2022年3月该院收治的92例乳腺癌肝转移患者进行前瞻性研究。对照组实施TX化疗方案治疗,观察组在对照组基础上联合射频消融术治疗,比较两组临床疗效、预后情况[无进展生存期(PFS)、复发、死亡]、治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)]水平和不良反应发生率。结果:观察组客观缓解率为47.83%(22/46),高于对照组的21.74%(10/46),差异有统计学意义(P<0.05);观察组PFS、复发、死亡情况比较,差异均无统计学意义(P>0.05);治疗后,两组ALT、AST水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:射频消融术联合TX化疗方案治疗乳腺癌肝转移患者可提高客观缓解率,以及降低肝功能指标水平的效果优于单纯TX化疗方案治疗。Objective:To observe effects of radiofrequency ablation combined with TX chemotherapy in treatment of breast cancer patients with liver metastasis.Methods:A prospective study was conducted on 92 patients with liver metastasis of breast cancer admitted to this hospital from January 2019 to March 2022.The control group was treated with TX chemotherapy,while the observation group was treated with radiofrequency ablation on the basis of that of the control group.The clinical efficacy,the prognosis[progression-free survival(PFS),recurrence,death],the liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The objective remission rate of the observation group was 47.83%(22/46),which was higher than 21.74%(10/46)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of ALT and AST in the two groups were lower than those before treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Radiofrequency ablation combined with TX chemotherapy in the treatment of the breast cancer patients with liver metastasis can improve the disease remission rate and reduce the levels of liver function indexes.Moreover,it is superior to simple TX chemotherapy.

关 键 词：射频消融术 化疗 乳腺癌肝转移 预后 肝功能 不良反应 

分 类 号：R735.7[医药卫生—肿瘤]