血塞通胶囊联合丁苯酞注射液治疗急性脑梗死患者的效果  

Effects of Xueshuantong capsules combined with Butylphthalide injection in treatment of patients with acute cerebral infarction

作　　者：王智忠 WANG Zhizhong(Department of Pharmacy Zhangjiachuan County First People’s Hospital,Tianshui 741500 Gansu,China)

机构地区：[1]张家川县第一人民医院药剂科,甘肃天水741500

出　　处：《中国民康医学》2024年第24期64-66,70,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察血塞通胶囊联合丁苯酞注射液治疗急性脑梗死患者的效果。方法:选取2022年12月至2023年12月该院收治的90例急性脑梗死患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各45例。对照组采用丁苯酞氯化钠注射液治疗,观察组在对照组基础上联合复方血栓通胶囊治疗。比较两组临床疗效,治疗前后脑血流动力学指标[大脑中动脉阻力指数(RI)、平均血流速度(Vm)]、神经功能指标[脑源性神经营养因子(BDNF)、神经肽Y(NPY)、脑胶质纤维酸性蛋白(GFAP)、同型半胱氨酸(Hcy)]、氧化应激指标[基质金属蛋白酶-9(MMP-9)、白细胞介素-6(IL-6)、髓过氧化物酶(MPO)、脂质过氧化物(LPO)]水平,以及不良反应发生率。结果:观察组治疗总有效率为91.11%,高于对照组的66.67%,差异有统计学意义(P<0.05);治疗后,两组RI水平均低于治疗前,且观察组低于对照组,两组Vm水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组BDNF水平均高于治疗前,且观察组高于对照组,两组NPY、GFAP、Hcy水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组MMP-9、IL-6、MPO、LPO水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:血栓通胶囊联合丁苯酞注射液治疗急性脑梗死患者可提高治疗总有效率,改善血流动力学指标和神经功能指标水平,以及降低氧化应激指标水平的效果优于单纯丁苯酞注射液治疗。Objective:To observe effects of Xueshuantong capsules combined with Butylphthalide injection in treatment of patients with acute cerebral infarction.Methods:A prospective study was conducted on 90 patients with acute cerebral infarction admitted to this hospital from December 2022 to December 2023.They were divided into control group and observation group according to the random number table method,45 cases in each.The control group was treated with Butylphthalide sodium chloride injection,while the observation group was treated with compound Xueshuantong capsules on the basis of that of the control group.The clinical efficacy,the levels of cerebral hemodynamic indexes[middle cerebral artery resistance index(RI),mean cerebral blood flow velocity(Vm)],neurological function indexes[brain-derived neurotrophic factor(BDNF),neuropeptide Y(NPY),glial fibrillary acidic protein(GFAP),homocysteine(Hcy)]and oxidative stress indexes[matrix metalloproteinase-9(MMP-9),interleukin-6(IL-6),myeloperoxidase(MPO),lipid peroxide(LPO)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 91.11%,which was higher than 66.67%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the RI levels of the two groups were lower than those before the treatment,and that in the observation group was lower than the that in control group;the Vm levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).The levels of BDNF in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of NPY,GFAP and Hcy in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were st

关 键 词：血栓通胶囊 丁苯酞注射液 急性脑梗死 脑血流动力学 神经功能 氧化应激 不良反应 

分 类 号：R743.33[医药卫生—神经病学与精神病学]