调强适形放疗对食管癌患者的治疗效果  

Effect of Intensity Modulated Radiotherapy in Patients with Esophageal Cancer

作　　者：亢崇照[1] 王晓宏[1] 李丹丹 朱小娟[1] 张建国 KANG Chongzhao;WANG Xiaohong;LI Dandan;ZHU Xiaojuan;ZHANG Jianguo(Department of Radiotherapy,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China;Department of Oncology,the 989 Hospital of PLA,Luoyang 471600,China)

机构地区：[1]河南科技大学第一附属医院放疗科,河南洛阳471000 [2]解放军九八九医院肿瘤科,河南洛阳471600

出　　处：《河南医学研究》2024年第24期4475-4478,共4页Henan Medical Research

摘　　要：目的 探讨采用调强适形放疗(IMRT)治疗食管癌患者的效果。方法 将2021年5月至2022年5月河南科技大学第一附属医院收治的80例食管癌患者作为此次研究对象,依据随机数字表法分为对照组(40例)和观察组(40例),均接受同步放化疗,给予对照组同步适形放疗,给予观察组IMRT同步治疗,均治疗4个周期。比较两组治疗4个周期后的近期疗效,不同时点食管癌患者生活质量专用量表(QLQ-OES24)评分,治疗前及治疗4周期后的免疫功能、肿瘤标志物。结果 治疗4个周期后,观察组的有效率(70.00%)高于对照组(47.50%)(P<0.05);两组患者治疗4个周期后、治疗结束后1个月的QLQ-OES24评分相比于治疗前均升高,且观察组评分高于对照组(P<0.05);相较于治疗前,两组治疗4个周期后的血清免疫球蛋白A(IgA)、免疫球蛋白M(IgM)和外周血CD3~+、CD4~+水平均降低,但观察组水平高于对照组(P<0.05);两组患者在治疗4个周期后的血清热休克蛋白90α(HSP90α)、细胞角蛋白片段19抗原21-1(Cyfra21-1)、糖类抗原125(CA125)、鳞状上皮细胞癌抗原(SCC-Ag)水平均降低,且观察组低于对照组(P<0.05)。结论 IMRT应用于食管癌患者可提升近期疗效,降低肿瘤标志物水平,对于免疫功能影响较小,可改善生活质量。Objective To explore the therapeutic effect of intensity modulated radiotherapy(IMRT)in patients with esophageal cancer.Methods A total of 80 patients with esophageal cancer admitted to the First Affiliated Hospital of Henan University of Science and Technology were divided into the control group(40 cases)and the observation group(40 cases).The cases were selected from May 2021 to May 2022,and the patients were grouped according to random number table method.Both groups were given concurrent chemoradiotherapy,and the control group was given synchronous conformal radiotherapy,the observation group was given synchronous IMRT therapy,both group were treated for 4 cycles of treatment.The short-term efficacy after 4 cycles of treatment,the scores of the quality of life questionnaire-oesophageal cancer module(QLQ-OES24)at different time points,the levels of immune function and tumor markers before and after 4 cycles of treatment were compared between the two groups.Results The short-term efficacy after 4 cycles of treatment was higher in the observation group(70.00%)than in the control group(47.50%)(P<0.05).The scores of QLQ-OES24 in both groups after 4 cycles of treatment,1 month after treatment increased compared with before treatment,and the scores of the observation group were higher than those of the control group(P<0.05).The level of serum immunoglobulin A(IgA),immunoglobulin M(IgM),and peripheral blood CD3+and CD4+in two groups after 4 cycles of treatment decreased compared with those before treatment,but the levels of observation group were higher than those of control group(P<0.05).The level of serum heat shock protein 90α(HSP90α),recombinant cytokeratin fragment antigen 21-1(Cyfra21-1),carbohydrate antigen 125(CA125),and squamous cell carcinoma antigen(SCC-Ag)in two groups after 4 cycles of treatment decreased compared with those before treatment,and the levels of observation group were lower than those of control group(P<0.05).Conclusion The application of MRT in patients with esophageal cancer can improve

关 键 词：食管癌 调强适形放疗 生活质量 免疫功能 肿瘤标志物 

分 类 号：R735.1[医药卫生—肿瘤]