血管细胞黏附分子1、P14Arf蛋白表达与脑胶质瘤患者肿瘤恶性程度及术后复发的关系  

Relationship Between Expressions of Vascular Cell Adhesion Molecule-1 and P14Arf Protein and Tumor Malignancy Degree and Postoperative Recurrence in Patients with Brain Glioma

作　　者：雷艳杰 赵舒杨 卜晓红[1] 宋艳芳[1] 马世杰[2] LEI Yanjie;ZHAO Shuyang;BU Xiaohong;SONG Yanfang;MA Shijie(Pathology Department,Zhoukou Central Hospital,Zhoukou 466000,China;Neurosurgery,Zhoukou Central Hospital,Zhoukou 466000,China)

机构地区：[1]周口市中心医院病理科,河南周口466000 [2]周口市中心医院神经外科,河南周口466000

出　　处：《河南医学研究》2024年第24期4479-4483,共5页Henan Medical Research

摘　　要：目的 探究血管细胞黏附分子1(VCAM-1)、P14Arf蛋白表达与脑胶质瘤患者肿瘤恶性程度及术后复发的关系。方法 收取102例经病理检查证实的脑胶质瘤组织标本(脑胶质瘤组)以及30例因颅脑损伤行内减压术患者的正常脑组织(对照组),通过免疫组织化学法检测血管VCAM-1和P14Arf蛋白的表达情况,比较各级别之间的表达差异。根据术后6个月复发情况分为复发组和未复发组,比较两组脑胶质瘤组织血管VCAM-1和P14Arf蛋白表达,分析各蛋白表达与临床病理的关系。结果 脑胶质瘤组中胶质瘤家族史、汽柴油接触史、射线或电磁场接触史、金属铅接触史、农药接触史、VCAM-1和P14Arf蛋白阳性率与对照组差异有统计学意义(P<0.05),性别、年龄、吸烟及饮酒差异无统计学意义(P>0.05);随着脑胶质瘤恶性程度的升高,VCAM-1高表达率逐渐上升,P14Arf蛋白高表达率逐渐下降,Ⅲ、Ⅳ级别脑胶质瘤患者VCAM-1和P14Arf蛋白高表达水平与Ⅰ、Ⅱ级患者比较,差异有统计学意义(P<0.05),而Ⅰ级、Ⅱ级患者间VCAM-1和P14Arf蛋白高表达差异无统计学意义(P>0.05);不同组织分化程度、Karnofsky评分患者VCAM-1和P14Arf蛋白表达差异有统计学意义(P<0.05);复发组VCAM-1高表达率及P14Arf蛋白低表达率高于未复发组(P<0.05)。结论 VCAM-1和P14Arf蛋白表达水平与脑胶质瘤病情进展及预后相关,可作为临床诊治的参考指标。Objective To explore the relationship between expressions of vascular cell adhesion molecule-1(VCAM-1)and P14Arf protein and tumor malignancy degree and postoperative recurrence in patients with brain glioma.Methods The tissue specimens of 102 patients with brain glioma confirmed by pathological examination(brain glioma group)and normal cerebral tissues of patients undergoing internal decompression due to craniocerebral injury(control group)were collected.The expressions of VCAM-1 and P14Arf protein in blood vessels were detected by immunohistochemistry,and the differences in expressions were compared among different grades.According to the recurrence at 6 months after surgery,the patients were divided into recurrence group and non-recurrence group.The expressions of VCAM-1 and P14Arf protein in brain glioma tissues were compared between both groups,and the relationship between the expression of each protein and clinical pathology was analyzed.Results The differences in family history of brain glioma,exposure history of naphtha and diesel oil,exposure history of radiation or electromagnetic field,metal lead exposure history,pesticide exposure history and positive rates of VCAM-1 and P14Arf protein were statistically significant between brain glioma group and control group(P<0.05),but there were no statistically significant differences in gender,age,smoking and drinking(P>0.05).With the increase of malignancy degree of brain glioma,the high expression rate of VCAM-1 was gradually increased while the high expression rate of P14Arf protein was gradually decreased,and the high expression levels of VCAM-1 and P14ARF protein in patients with gradeⅢorⅣbrain glioma were statistically different compared with those in patients with grade I orⅡbrain glioma(P<0.05),but there were no statistical differences in the expressions of VCAM-1 and P14Arf protein between grade I patients and gradeⅡpatients(P>0.05).The expressions of VCAM-1 and P14Arf protein among patients with different tissue differentiation degrees and Karn

关 键 词：脑胶质瘤 血清细胞间黏附分子1 P14ARF蛋白 

分 类 号：R739.41[医药卫生—肿瘤]