The cascade regulation of small RNA and quorum sensing system: Focusing on biofilm formation of foodborne pathogens in food industry  

作　　者：Ying Zhang Qingping Wu Stephen Forsythe Chengcheng Liu Nuo Chen Yangfu Li Jumei Zhang Juan Wang Yu Ding 

机构地区：[1]Institute of Microbiology,Guangdong Academy of Sciences,State Key Laboratory of Applied Microbiology Southern China,Key Laboratory of Agricultural Microbiomics and Precision Application,Ministry of Agriculture and Rural Affairs,Guangdong Provincial Key Laboratory of Microbial Safety and Health,Guangzhou,510070,China [2]Department of Food Science&Technology,Institute of Food Safety&Nutrition,Jinan University,Guangzhou,510632,China [3]Foodmicrobe.com,Keyworth,Nottingham,NG125GY,UK [4]College of Food Science,South China Agricultural University,Guangzhou,510432,China

出　　处：《Food Bioscience》2023年第2期117-125,共9页食品生物科学（英文）

基　　金：This work was supported by National Natural Science Foundation of China(32272424);Guangdong Major Project of Basic and Applied Basic Research(2020B0301030005);Guangdong Provincial Key Laboratory(2020B121201009);Guangdong Academy of Sciences Special Project for Capacity Building of Innovation Driven Development(2020GDASYL-20200401002).

摘　　要：Biofilms containing foodborne pathogens can adhere to food ingredients or food processing equipment.Due to their enhanced resilience to cleaning and chance of cross-contamination,there is an increased risk of food poisoning to consumers.The life course of biofilms is generally thought to be regulated by a quorum sensing(QS)system by secreted autoinducing peptides(AIPs).Recent studies have revealed that small non-coding RNA(sRNA)also plays an important role in regulating biofilm formation at the post-transcriptional level.Moreover,sRNA can act as an intermediate regulating hub between the quorum sensing system and biofilm.This review summarizes the latest findings on sRNA in biofilms of common foodborne pathogens and their potential impact.We also highlight the different mechanism of cascade regulation of sRNA and QS system in biofilm formation in several typical foodborne pathogens.In this process,sRNA responds to dynamic external environmental signals finely and accurately,and can feedback information on the bacterial cell environment to modify the QS system.These findings will deepen our understanding of biofilm formation and provide new perspectives for eliminating biofilm of foodborne pathogens based on the cascade regulation of small RNA and QS for developing biofilm-free food-processing systems.

关 键 词：Foodborne pathogens BIOFILM Small non-coding RNA Quorum sensing Two-component system Stress response 

分 类 号：TS201.3[轻工技术与工程—食品科学]