Pharmacokinetic profile and sub-chronic toxicity of coenzyme Q_(10) loaded whey protein nanoparticles  

作　　者：Cuina Wang Ru Zhao Keyi He Siyu Zhang Alyssa H.Kemp Mingruo Guo 

机构地区：[1]Department of Food Science,Jilin University,Changchun,China [2]Department of Food Science,Northeast Agriculture University,Harbin,China [3]Department of Nutrition and Food Sciences,College of Agriculture and Life Sciences,University of Vermont,Burlington,VT,05405,USA

出　　处：《Food Bioscience》2023年第2期215-223,共9页食品生物科学（英文）

摘　　要：Coenzyme Q_(10)(CoQ_(10))is a crucial endogenous lipophilic antioxidant,and encapsulation is often used to improve its solubility and stability.However,information about the bioavailability and safety assessment of constructed formulations is limited.In this study,in vivo pharmacokinetics profile and sub-chronic toxicity of CoQ_(10) loaded whey protein concentrate(WPC)and polymerized whey protein concentrate(PWPC)nanoparticles were evaluated.Pharmacokinetics data showed that CoQ_(10) concentrations in the plasma of rats fed with nanoparticles were higher than that of the free counterpart.CoQ_(10) concentration reached its maximum level after 12 h when orally administered with WPC and PWPC based encapsulation,which was delayed compared with free CoQ_(10)(8 h).Sub-chronic toxicity evaluation for PWPC-CoQ_(10) was conducted with 28-day feeding test.Results indicated that no adverse toxicological reactions in term of physical examination,body weight,food intake,hematology,serum chemistry,organ weight or histopathology excepted for blood potassium were observed after oral administration of feed with incorporated PWPC-CoQ_(10) nanoparticles.The maximum concentration of nanoparticle powder in diet of no adverse effect on the male and female rats was up to 2%(w/w).Results denoted a potential application of whey protein as a safe natural polymer to fabricate delivery systems to enhance bioavailability of nutritional supplements like CoQ_(10).

关 键 词：Coenzyme CoQ_(10) Whey protein Pharmacokinetic study Sub-chronic toxicity 

分 类 号：TS201.2[轻工技术与工程—食品科学]