A pH-driven method for liposomal encapsulation of dietary flavonoid rutin: Sustained release and enhanced bioefficacy  

作　　者：Priti Sengupta Debashree Das Sampurna Bhattacharya Runa Sur Adity Bose Kamalika Sen 

机构地区：[1]Department of Chemistry,University of Calcutta,92 APC Road,Kolkata,700009,India [2]Department of Chemistry,Presidency University,86/1 College Street,Kolkata,700073,India [3]Department of Biophysics,Molecular Biology&Bioinformatics,University of Calcutta,92 APC Road,Kolkata,700009,India

出　　处：《Food Bioscience》2023年第2期378-384,共7页食品生物科学（英文）

基　　金：This work was supported by WBDST,West Bengal(Project no.546(sanc.)/ST/P/S&T/4G-13/2014);the FRPDF grant from Presidency University,Kolkata,India.

摘　　要：Dietary polyphenols offer a wide range of health benefits in functional food,nutraceutical,as well as pharmaceutical industries.Their practical applications,however,encounter several challenges due to limited solubility and bioavailability.In the present study,we have developed a pH-driven method to prepare rutin-loaded liposomes which were characterized by evaluating particle size,polydispersity index(PDI),zeta potential,TEM,and encapsulation efficacy.The IC50 value of encapsulated rutin for HeLa cells was 250μmol/L,while free rutin shows insignificant inhibitory effect.Besides,the bioaccessibility of rutin enhanced from 9.8%to 19.7%upon liposomal encapsulation.The percentage release of free rutin in SGF and SIF was~98.4%and~98.7%respectively within 6 h.However,upon encapsulation,less than 55%was released even after 24 h.Overall,the enhanced bioaccessibility,reduced cell viability of HeLa cells,and most importantly,sustained release for rutin-loaded liposomes,accounted for the favorable outcome of our approach.

关 键 词：pH-driven method RUTIN ENCAPSULATION Liposome Flavonoid Bioactivity 

分 类 号：TS201.2[轻工技术与工程—食品科学]