Efficacy of Eisenia bicyclis phlorotannins in the treatment of diabetes and reducing inflammation  

作　　者：Rathinam Raja Shanmugam Hemaiswarya Kulanthaiyesu Arunkumar N.Mathiyazhagan Sabariswaran Kandasamy A.Arun P.Ramasamy 

机构地区：[1]Research and Development Wing,Sree Balaji Medical College and Hospital(SBMCH),Bharath Institute of Higher Education and Research(BIHER),Chennai,600044,India [2]Department of Biotechnology,IIT Madras,Chennai,600036,India [3]Department of Plant Science,Central University of Kerala,Periye,671320,Kasaragod,Kerala,India [4]Division of Research and Innovation,Department of Biotechnology,Saveetha School of Engineering,Saveetha Institute of Medical and Technical Science,Chennai,600052,India [5]Water-Energy Nexus Laboratory,Department of Environmental Engineering,University of Seoul,Seoul,02504,Republic of Korea [6]Bioenergy and Bioremediation Laboratory,Department of Microbiology,Alagappa University,Karaikudi,India

出　　处：《Food Bioscience》2023年第2期404-411,共8页食品生物科学（英文）

摘　　要：Crude phlorotannins from Eisenia bicyclis(CPEb),a common perennial brown seaweed were screened for pharmacological activities such as anti-inflammatory,antioxidant,and antidiabetic effects.Crude Phlorotannins(CPEb)studied by FT-IR,LC-MS,UHPLC,and UV chromatography showed the occurrence of dieckol,8,8’-bieckol,fucofuroeckol,and the carotenoid,zeaxanthin(0.5 mg/kg).LPS,an inflammatory mediator,enhanced the production of cytokines such IL-1(interleukin-1),IL-6(interleukin-6),IL-8(interleukin-8),IL-10(interleukin-10),TNF-α(tumour necrosis factor-α),chemokine CXCL10,and NF-κB(nuclear factor kappa-light-chain-enhancer of activated B cells)in differentiated THP1 macrophage cells.On differentiated human monocytic cell line LPS-induced THP1 cells,CPEb was found to have anti-inflammatory effects by reducing the expression of IL-1,IL-6,IL-8(1.2 fold),CXCL10,NF-κB,and TNF-α.CPEb promoted 2-NBDG absorption in differentiated C2C12 myotubes under both basal(16.08%)and insulin-stimulated(51.09%)conditions.CPEb increased IRS/AKT-dependent glucose absorption and also activates the AMPK pathway.Anti-α-glucosidase,anti-inflammatory and antioxidant activity of CPEb indicate their role in treating hyperglycemia by scavenging ROS and inflammatory responses.

关 键 词：Seaweeds Eisenia bicyclis ANTIOXIDANT ANTIDIABETIC ANTI-INFLAMMATORY 

分 类 号：TS201[轻工技术与工程—食品科学]