Grape seed extract improves intestinal barrier integrity and performance: Evidence from in vitro, Caenorhabditis elegans and Drosophila melanogaster experiments and a study with growing broilers  

作　　者：Georg Sandner Verena Stadlbauer Nadiia Sadova Cathrina Neuhauser Bettina Schwarzinger Lea Karlsberger Kerstin Hangweirer Katharina Antensteiner Alexander Stallinger Tobias Aumiller Julian Weghuber 

机构地区：[1]Center of Excellence Food Technology and Nutrition,University of Applied Sciences Upper Austria,Stelzhamerstraße 23,Wels,4600,Austria [2]FFoQSI GmbH-Austrian Competence Centre for Feed and Food Quality,Safety and Innovation,Technopark 1D,Tulln,3430,Austria [3]Delacon Biotechnik GmbH,Langwiesen 24,Engerwitzdorf,4209,Austria

出　　处：《Food Bioscience》2023年第2期1128-1136,共9页食品生物科学（英文）

摘　　要：Grape seed extract(GSE)is an interesting source for polyphenols and other phytochemicals with high antioxidant potential.Here,we report on a comprehensive study investigating GSE in various in vitro and in vivo experiments.Obtained results indicate that GSE improves parameters related to intestinal barrier integrity in cell culture,C.elegans and D.melanogaster.Faster wound healing was observed in a scratch assay using intestinal IPEC-J2 cells when pre-treated with GSE.Furthermore,reactive oxygen species were found to be significantly decreased in cell culture and C.elegans experiments.In C.elegans,qPCR gene expression analysis revealed significant modulations after 24 h of GSE treatment.Finally,a 42-day broiler feeding study revealed a dose dependant effect on growth performance in the GSE supplemented groups.In conclusion,GSE was found to provide promising properties including wound closure,intestinal integrity,and antioxidant activity.

关 键 词：Intestinal functionality Intestinal barrier Grape seed extract C.elegans D.melanogaster BROILER Oxidative stress 

分 类 号：TS201.3[轻工技术与工程—食品科学]