不同他汀类药物治疗大动脉粥样硬化性急性脑梗死的临床效果观察  

Clinical Effect of Different Statins in the Treatment of Acute Cerebral Infarction of Large Arteries

作　　者：龚柳盛 宋正希 付钟[1] Gong Liusheng;Song Zhengxi;Fu Zhong(Jianyang People's Hospital,Chengdu 641400,Sichuan Province,China)

机构地区：[1]简阳市人民医院,四川成都641400

出　　处：《中外医药研究》2024年第31期36-38,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：成都市医学科研课题(编号:2022261)。

摘　　要：目的:分析不同他汀类药物治疗大动脉粥样硬化性急性脑梗死的价值。方法:选取2021年1月—2024年1月简阳市人民医院收治的大动脉粥样硬化性急性脑梗死患者96例纳入研究,随机分成阿托伐他汀组(接受阿托伐他汀治疗)、瑞舒伐他汀组(接受瑞舒伐他汀治疗)以及匹伐他汀组(接受匹伐他汀治疗),各32例。对比三组血脂水平、神经功能及不良反应发生率。结果:治疗后,三组总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平降低,高密度脂蛋白胆固醇水平升高,瑞舒伐他汀组优于阿托伐他汀组、匹伐他汀组,阿托伐他汀组优于匹伐他汀组(P<0.05);治疗后,三组美国国立卫生研究院量表评分降低,瑞舒伐他汀组低于阿托伐他汀组、匹伐他汀组,阿托伐他汀组低于匹伐他汀组(P<0.05);瑞舒伐他汀组不良反应发生率低于匹伐他汀组(P=0.010)。结论:阿托伐他汀、瑞舒伐他汀、匹伐他汀均能够降低大动脉粥样硬化性急性脑梗死患者的血脂水平,改善神经功能,但瑞舒伐他汀效果较好,且不良反应较少,其次为阿托伐他汀。Objective:To analyze the value of different statins in the treatment of acute cerebral infarction of large arteries.Methods:Ninety-six patients with acute cerebral infarction of large arteries admitted to Jianyang People's Hospital from January 2021 to January 2024 were included in the study,and were randomly divided into atorvastatin group(receiving atorvastatin treatment),rosuvastatin group(receiving rosuvastatin treatment)and pivastatin group(receiving pivastatin treatment),with thirtytwo cases each.Blood lipid level,nerve function and incidence of adverse reactions were compared among the three groups.Results:After treatment,the levels of total cholesterol,triglyceride and low-density lipoprotein cholesterol decreased and the levels of high-density lipoprotein cholesterol increased in the three groups,rosuvastatin group was better than atorvastatin group and pivastatin group,and atorvastatin group was better than pivastatin group(P<0.05);after treatment,the National Institutes of Health Scale Scores of the three groups were decreased,and the rosuvastatin group was lower than atorvastatin group and pivastatin group,and atorvastatin group was lower than pivastatin group(P<0.05);the incidence of adverse reactions in rosuvastatin group was lower than that in pivastatin group(P=0.010).Conclusion:Atorvastatin,rosuvastatin and pivastatin can all reduce blood lipid level and improve nerve function in patients with acute cerebral infarction of large arteries,but rosuvastatin has better effect and less adverse reactions,followed by atorvastatin.

关 键 词：阿托伐他汀 瑞舒伐他汀 匹伐他汀 动脉粥样硬化 急性脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]