尼莫地平与阿司匹林治疗偏头痛的临床效果对比  

Comparision of Clinical Effect of Nimodipine and Aspirin in the Treatment of Migraine

作　　者：姚惟刚 Yao Weigang(Yangtze River Hospital of Yangtze River Water Resources Commission(Schistosomiasis Control and Monitoring Center),Wuhan 432100,Hubei Province,China)

机构地区：[1]长江水利委员会长江医院(血吸虫病防治监测中心),湖北武汉432100

出　　处：《中外医药研究》2024年第31期69-71,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:对比尼莫地平与阿司匹林治疗偏头痛的临床效果。方法:选取长江水利委员会长江医院2019年2月—2023年10月收治的200例偏头痛患者为研究对象,随机分为对照组和观察组,各100例。对照组采用尼莫地平治疗,观察组采用阿司匹林治疗。对比两组治疗总有效率、不良反应发生率、疼痛程度、临床指标及经颅多普勒超声检查结果。结果:观察组治疗总有效率高于对照组(P<0.001)。观察组不良反应发生率低于对照组(P<0.001)。治疗前,两组视觉模拟评分对比,无统计学差异(P>0.05);治疗后,两组视觉模拟评分降低,观察组低于对照组(P<0.05)。治疗前,两组头痛持续时间和发作次数对比,无统计学差异(P>0.05);治疗后,两组头痛持续时间缩短,发作次数均减少,观察组优于对照组(P<0.05)。治疗前,两组双侧大脑中动脉最大血流速度及平均血流速度对比,无统计学差异(P>0.05);治疗后,两组双侧大脑中动脉最大血流速度及平均血流速度降低,观察组低于对照组(P<0.05)。结论:与尼莫地平相比,阿司匹林治疗偏头痛的效果较好,能够减轻头痛症状,优化脑动脉血流量,不良反应较少。Objective:To compare the clinical effect of nimodipine and aspirin in the treatment of migraine.Methods:A total of two hundred migraine patients admitted to Yangtze River Hospital of Yangtze River Water Resources Commission from February 2019 to October 2023 were selected as the study objects,and randomly divided into control group and observation group,with one hundred patients in each group.The control group was treated with nimodipine,and the observation group was treated with aspirin.The total effective rate,incidence of adverse reactions,pain degree,clinical indexes and transcranial Doppler ultrasound results were compared between the two groups.Results:The total effective rate of observation group was higher than that of control group(P<0.001);the incidence of adverse reactions in observation group was lower than that in control group(P<0.001).Before treatment,there was no significant difference in visual analogue scores between the two groups(P>0.05);after treatment,the visual analog scores of both groups were decreased,and the observation group was lower than the control group(P<0.05).Before treatment,there was no significant difference in the duration and frequency of headache between the two groups(P>0.05);after treatment,the duration of headache was shortened and the number of attacks was reduced in both groups,and the observation group was better than the control group(P<0.05).Before treatment,there was no significant difference in the maximum and average blood flow velocity of bilateral middle cerebral artery between the two groups(P>0.05);after treatment,the maximum and average blood flow velocity of bilateral middle cerebral artery decreased in both groups,and the observation group was lower than the control group(P<0.05).Conclusion:Compared with nimodipine,aspirin is more effective in the treatment of migraine,reducing headache symptoms,optimizing cerebral arterial blood flow,and fewer adverse effects.

关 键 词：尼莫地平 阿司匹林 偏头痛 不良反应 

分 类 号：R747.2[医药卫生—神经病学与精神病学]