亚甲蓝治疗血管麻痹综合征的应用进展  

Progress in the Application of Methylene Blue in the Treatment of Vasoplegic Syndrome

作　　者：张春虎 Zhang Chunhu(The First Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310000,Zhejiang Province,China)

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310000

出　　处：《中外医药研究》2024年第32期166-168,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：该文分析了亚甲蓝用于治疗血管麻痹综合征的作用机制、疗效及其临床应用现状。通过总结现有文献中的相关研究内容,阐述了亚甲蓝在恢复血管张力调节中的潜在机制,包括其通过阻断可溶性鸟苷酸环化酶表达在内皮细胞功能恢复中的作用,以及通过恢复血管自身调节作用达到稳定循环的效果。讨论了亚甲蓝使用时机及其安全性问题。亚甲蓝在治疗血管麻痹综合征方面展示了良好的前景,但需进一步研究以明确其最佳应用方案,并确保患者的安全与疗效。This article analyzed the mechanism,effect and clinical application of methylene blue in the treatment of Vasoplegic syndrome.By summarizing the relevant studies in the existing literature,the potential mechanism of methylene blue in restoring vascular tone regulation was described,including its role in endothelial cell function recovery by blocking the expression of soluble guanylate cyclase,and the effect of stabilizing circulation by restoring vascular autoregulation.The timing and safety of methylene blue were discussed.Methylene blue shows promise in the treatment of Vasoplegic syndrome,but further research is needed to determine the optimal use of methylene blue injection and ensure patient safety and efficacy.

关 键 词：血管麻痹综合征 亚甲蓝 血管张力 

分 类 号：R739.91[医药卫生—肿瘤]