Association of eczema with risk of pan-cancers:a two-sample Mendelian randomization study  

作　　者：Xixi Zhao Xinyu He Xiaoxiao Liu Shangyi Geng Yuchen Wang Yongze Dang Ruijuan Zhang Xinran Huang Wei Guo Hongbing Ma 

机构地区：[1]Department of Radiation Oncology,The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an,China

出　　处：《Oncology and Translational Medicine》2024年第6期262-271,共10页肿瘤学与转化医学（英文版）

基　　金：supported by the National Natural Science Foundation of China(no.82374229 and 82172839).

摘　　要：Background:Both eczema and tumor are associated with immune disorders.Although several investigations have observed the rela-tionship between eczema and certain cancers,evidence for causality is lacking.Methods:We conducted a two-sample Mendelian randomization(MR)study to examine and explore the genetic association between eczema and pan-cancers.Upon satisfying the three core assumptions of MR,we analyzed the causality between eczema and 15 site-specific cancers utilizing an inverse variance weighted method.We verified the results through a series of sensitivity and reverse direction analyses.The exposure and outcome datasets were substituted from the FinnGen and genome-wide association studies catalog data-bases.A meta-analysis on primary and validation analyses was performed to combine the estimates of MR study.Results:Based on the MR analysis results,eczema was associated with an increased risk of lung cancer(odds ratio[OR]=1.0427,95%confidence interval[CI]=1.0082–1.0783,P=0.0148)and brain cancer(OR=1.0285,95%CI=1.0120–1.0452,P=0.0007)and de-creased risk of colorectal cancer(OR=0.9324,95%CI=0.8774–0.9909,P=0.0242)and malignant neoplasm of the kidney(OR=0.9323,95%CI=0.8834–0.9839,P=0.0108).The sensitivity analysis indicated that the results were stable and reliable,and the reverse MR analyses demonstrated no causation between the cancers of interest and eczema.Conclusions:Our results identified eczema as a genetic risk factor for lung and brain cancer and a protective factor for colorectal cancer and malignant neoplasm of the kidney.No connection was observed between eczema and other cancers.Further evidence from epide-miological and mechanistic studies is needed to elucidate these findings in detail.

关 键 词：Causal relationship ECZEMA Mendelian randomization Pan-cancer Genome-wide association study 

分 类 号：R730[医药卫生—肿瘤] R758.23[医药卫生—临床医学]