Transformation of lung adenocarcinoma into small cell lung cancer after treatment with epidermal growth factor receptor tyrosine kinase inhibitors  

作　　者：Linwu Kuang Yangkai Li 

机构地区：[1]Department of Thoracic Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China

出　　处：《Oncology and Translational Medicine》2024年第6期286-291,共6页肿瘤学与转化医学（英文版）

摘　　要：Epidermal growth factor receptor tyrosine kinase inhibitors effectively improve the prognosis of patients with epidermal growth factor receptor–mutant lung adenocarcinoma.However,acquired resistance inevitably develops with small cell lung cancer transformation emerging as a rare but increasingly frequent mechanism of tyrosine kinase inhibitor resistance.This transformation poses significant chal-lenges to the health of patients with lung cancer and complicates their clinical management.This article comprehensively reviews the di-agnostic,predictive,mechanistic,and therapeutic aspects of small cell lung cancer transformation to enhance our understanding and clin-ical awareness of this phenomenon.

关 键 词：Small cell lung cancer transformation Lung adenocarcinoma EGFR-TKIS SCLC Drug resistance 

分 类 号：R734.2[医药卫生—肿瘤]